天津医药

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急性脑梗死患者血小板参数的临床分析

李永乐1,李新1,王栋梁2,王纪佐3   

  1. 1. 天津医科大学第二医院神经内科
    2. 天津医科大学第二医院
    3.
  • 收稿日期:2011-07-18 修回日期:2011-11-14 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 李新

Clinical analysis of the platelet parameters in 2109 cases of acute cerebral infarction

  • Received:2011-07-18 Revised:2011-11-14 Published:2012-05-15 Online:2012-05-15

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摘要： 【摘要】 目的 研究急性脑梗死患者平均血小板体积(MPV)、血小板计数(PLT)、血小板分布宽度 (PDW)的特点及临床意义。 方法 对急性脑梗死2109例患者的MPV、PLT、PDW进行回顾性分析，并与480名健康体检者的血小板参数进行对比，分析不同脑卒中危险因素对血小板参数的影响，同时对首次脑梗死患者与复发脑梗死患者的血小板参数进行比较分析。结果 急性脑梗死患者组的MPV明显高于健康对照组（P<0.05），而PLT、PDW与对照组相比无明显差异（P>0.05）。单纯脑梗死组、高血压合并脑梗死组、糖尿病合并脑梗死组、血脂异常合并脑梗死组、房合并脑梗死组之间比较MPV、PLT水平差异有统计学意义（P<0.05）。单纯脑梗死组MPV较其他组减小（P<0.01）；房颤合并脑梗死组MPV较其他组均增大（P<0.05），其PLT较高血压组、血脂异常组减少（P<0.05）；高血压合并脑梗死组、糖尿病合并脑梗死组、血脂异常合并脑梗死组之间MPV、PLT、PDW差异无统计学意义（P>0.05）。复发脑梗死组与首次脑梗死组MPV、PLT、PDW比较无统计学差异（P>0.05）结论 MPV增大可能是脑梗死的一项独立危险因素，检测MPV对急性脑梗死的预防有重要意义，尤其对高血压、糖尿病、房颤、血脂异常患者检测MPV更有意义，应建议其早期进行抗血小板治疗。

关键词: 急性脑梗死, 血小板参数, 脑卒中危险因素, 脑梗死复发

Abstract: Abstract Objective: To study the characteristics and clinical significance of platelet count (PLT)、mean platelet volume(MPV) and platelet distribution width (PDW) in patients with acute cerebral infarction．Methods: The parameters of blood platelet (PLT、 MPV、 PDW) were detected in 2109 patients with acute cerebral infarction and compared with the control group(480 healthy persons )．To analysis the characteristics of platelet parameters exposed in different risk factor for stroke, and then to compare the characteristics of platelet parameters in first cerebral infarctions and recurrent cerebral infarctions . Results: MPV in acute cerebral infarction was obviously higher than ones in control group(P<0．05)， while PLT and PDW, there were no significant differences in all results(P>0．05)． The difference of the groups that Pure cerebral infarction group, high blood pressure with cerebral infarction group, diabetes combined with cerebral infarction group, dyslipidemia with cerebral infarction group, has statistical significance (P < 0.05), PDW difference has no statistically significant(P > 0.05). MPV in the pure cerebral infarction was obvious lower than other groups(P < 0.01); MPV in Af with cerebral infarction group was higher than other groups, the difference was statistically significant (P < 0.05),its PLT is less than high blood pressure group, or the dyslipidemia group, statistical significance was found (P < 0.05), PDW difference were not significant with the other groups (P > 0.05); The differences of MPV, PLT, PDW in High blood pressure with cerebral infarction group, diabetes combined with cerebral infarction group, dyslipidemia cerebral infarction group, have no statistically significant (P > 0.05). The difference of PLT, PDW, MPV between recurrence of cerebral infarction and cerebral infarction group for the first time, have no statistical difference (P > 0.05) Conclusions: The increased MPV may be a independent risk factors of cerebral infarction, so it is important to detecte MPV for the prevention of acute cerebral infarction, especially for patiens with high blood pressure, diabetes, atrial fibrillation, and dyslipidemia , the early antiplatelet therapy should be advised.

Key words: acute cerebral infarction, platelet parameters, stroke risk factors, cerebral infarction recurrence