天津医药

• 论著 • 上一篇    下一篇

单纯性肥胖患者血清瘦素水平与尿微量白蛋白关系的研究

李颖1,夏天1,李荣2   

  1. 1. 天津医科大学第二医院
    2. 天津医大二院肾内科
  • 收稿日期:2011-06-09 修回日期:2011-09-19 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 夏天

Correlation between serum leptin and urine micro-albumin in patients with simple obesity

  • Received:2011-06-09 Revised:2011-09-19 Published:2012-05-15 Online:2012-05-15

PDF (PC)

2363

摘要： 摘要 目的:研究单纯性肥胖(simple obesity)患者血清瘦素(leptin，LEP)水平与尿微量白蛋白的相关性，探讨瘦素对肾脏的影响。方法：选取单纯性肥胖患者(肥胖组)60例；另选取与肥胖组年龄相匹配的正常对照者(对照组)40例，采用放射免疫分析法测定受试者空腹血清瘦素水平，同时测定身高、体重、腰围、臀围、收缩压、舒张压、血糖、血脂、肾功能、尿微量白蛋白、尿肌酐，计算体重指数（BMI）、腰臀比（WHR）、平均动脉压（MAP）及尿微量白蛋白/尿肌酐比值（UACR）。结果:肥胖组血清LEP水平及UACR均明显高于对照组（P<0.01）。肥胖组血清LEP水平与BMI和WHR均呈明显正相关（r =0.650 sv r =0.617，P<0.01），与血糖呈正相关（r =0.345，P<0.05），与UACR无相关性（r = -0.146,P>0.05）。结论:单纯性肥胖可导致血清LEP水平及UACR明显增加，但二者无相关性。

关键词: 单纯性肥胖, 体重指数, 血清瘦素, 尿微量白蛋白/尿肌酐比值, 肾脏损伤

Abstract: Abstract Objective:To study the correlation between serum leptin (LEP) level and urine micro-albumin in patients with simple obesity,discuss the effects of leptin on kidneys . Methods:60 patients with simple obesity and 40 controls in this study. Height,body weight,waist circumference,hip circumference,systolic blood pressure, diastolic blood pressure,blood glucose, total cholesterol, triglyceride,blood urea nitrogen,serum creatinine, uric acid ,urine micro-albumin, urine creatinine as well as serum leptin were observed in each group and compared. Meanwhile, body mass index(BMI) , waist-hip ratio(WHR) ,mean arterial pressure(MAP) and the ratio of urine micro-albumin and urine creatinine(UACR) were counted. Results: In compare with control group,serum LEP and UACR in obese group were significantly increased(P<0.01). Serum LEP in obese group was in a positive correlation with BMI (r =0.650,P<0.001),WHR (r =0.617,P<0.001) and blood glucose (r =0.345,P<0.05),but had not significant correlation with UACR(r = -0.146,P>0.05). Conclusion: The level of serum LEP and UACR are related to obesity.But there is not significant correlation between serum LEP and UACR.

Key words: simple obesity, body mass index, serum leptin, the ratio of urine micro-albumin and urine creatinine, kidney injury