关键词: 颈动脉支架术, 凝血因子, 并发症

Abstract: [Abstract] Objective  To observe the serum changes of coagulation factor and inflammatory factor in patients with carotid artery stenosis after carotid artery stent operation, and discuss the possible relationship between these changes and postoperative complications. Methods  The clinical data of 62 patients with carotid artery stenosis from 2009 to 2012 in our hospital were retrospectively analyzed. Patients were divided into two groups according to the therapeutic method, including stent implantation group (n=22) and normal angiography group (n=40). The serum levels of coagulation factor and inflammatory factor were detected 1, 3 and 7 days after operation in two groups. Results  There were no significant differences in serum coagulation factor and inflammatory factor before operation between two groups. The serum level of coagulation factor recovered to near the preoperative level after 7 days in two groups. There were higher levels of prothrombin time (PT), D-dimer (DD) and fibrinogen degradationproduct(FDP)1dayafteroperationinstentimplantationgroupthanthoseofnormalangiographygroup.Theserumlevels ofcoagulationfactors weresignificantlyhigher3daysafteroperationandFDP wassignificantyhigher7daysafteroperationinstent implantationgroupthanthoseofnormalangiographygroup.Thelevelsofhigh-sensitivityC-reactiveprotein(hs-CRP),interleukin (IL)-6 and IL-8 were significantly higher in normal angiography group 1 day after operation. There were significant differences in hs-CRP(1dayafteroperation)andIL-8(1dayand3daysafteroperation，andbeforeoperation)instentimplantationgroup.Other serum coagulation factors showed significant changes after operation and continued for 1 week. There were significant differences in hs-CRP (1 day and 7 days after operation)tumor necrosis factor (TNF)-α (1, 3 and 7 days after operation）, IL-6（3 and 7 days after operation）and IL-8（1 and 3 days after operation）between stent implantation group and normal angiography group. The incidence of complication was significantly higher in stent implantation group（40.9%）than that of angiography group（2.5%）. Conclusion  The carotid artery stent implantation has a significant impact on serum coagulation factor and inflammatory factor, and serum coagulation factor rises to 1 week after operation.