关键词: 胎血, 血红蛋白类, α地中海贫血, 血蛋白电泳, 血红蛋白测定, 婴儿, 新生, 贵阳

Abstract:

[Abstract] Objective  To investigate the prevalence of α-thalassemia in population of Guiyang city, and explore the relative amount of each hemoglobin(Hb) type among the newborn infants with different gestational weeks. Methods  A total of 1 222 cord blood samples from newborn infants, whose parents were both Guiyang citizen, with different gestational weeks were collected. The hemoglobin electrophoresis was performed on these cord blood samples by Sebia automatic electrophoresis apparatus to explore the prevalence and types of α-thalassemia in population of Guiyang city according to the detection rate and relative amount of Hb Bart’s. The newborn infants were divided into 5 groups according to gestational weeks, and the relative amounts of each hemoglobin type were compared between 5 groups. Results  Out of the 1 222 cord blood samples, 36 were detected to have Hb Bart’s with the detection rate 2.95%. Among the 36 cases with positive Hb Bart’s, 23 cases were α-thalassemia minor, 12 cases were silent α-thalassemia and 1 case was α-thalassemia intermedia. No one case was α-thalassemia major. Two cases of abnormal hemoglobin were identified, both were Hb J, and the detection rate was 0.16%. The major hemoglobin type of newborn infant was Hb F, accounting for more than 75% of the total hemoglobin. The relative amount of Hb F showed a gradually decrease while Hb A increase with increasing gestational age.Conclusion  Guiyang city is a high prevalence area of α-thalassemia. The relative amount of each hemoglobin type showed a dynamic change with increasing gestational age.

Key words: fetal blood, hemoglobins, alpha-thalassemia, blood protein electrophoresis, hemoglobinometry, infant, newborn, 贵阳