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阻塞型睡眠呼吸暂停低通气综合征真胰岛素、胰岛素原与体脂分布的相关性研究

叶贤伟1,张湘燕2,文炜2,冯端兴2   

  1. 1. 贵州省人民医院呼吸内科-贵州省呼吸疾病研究所
    2.
  • 收稿日期:2009-09-17 修回日期:2009-11-03 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 叶贤伟

Relationships of true insulin and proinsulin to Body fat distribution in patients with obstructive sleep apnea-hypopnea syndrome

  • Received:2009-09-17 Revised:2009-11-03 Published:2010-08-15 Online:2010-08-15
  • Contact: ye xian wei

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摘要： 目的: 研究阻塞型睡眠呼吸暂停低通气综合征（OSAHS）中血清真胰岛素（TI）、胰岛素原（PI）与体脂分布的相关性。方法: 根据呼吸暂停低通气指数（AHI）将72例确诊OSAHS患者分为轻度组、中度组及重度组三组，同时选择15例健康正常人作为对照组，采用高度特异性的ELISA法分别检测空腹血清TI、PI水平，同时测定体重指数（BMI）、腰围（WC）、颈围（NC）。结果: OSAHS患者血清TI、PI的水平均高于健康对照组（P＜0.05）。OSAHS各亚组间的比较发现：中、重度组的TI、PI水平明显高于轻度组（P＜0.05）。pearson相关分析提示 OSAHS患者血清TI、PI与BMI、WC、NC呈正相关。结论: OSAHS患者血清TI、PI的水平与体脂分布存在相关性。

关键词: 阻塞型睡眠呼吸暂停低通气综合征, 真胰岛素, 胰岛素原, 体重指数、腰围、颈围

Abstract: objective: To study the relationship between serum true insulin(TI), proinsulin(PI) and their body fat distribution in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods: 72 diagnosed cases were divided into three groups,mild group,moderate group and severe group according to apnea hypopea index(AHI),meanwhile 15 healthy people were selected as control group. the serum TI,PI and body mass index(BMI),waist circumference(WC),neck circumference(NC) were detected. Results: The levels of PI and TI were higher in OSAHS group than healthy group,and there were statistically significant differences among four groups.pearson analysis indicated that the levels of TI and PI were positively correlated with BMI,WC and NC in OSAHS patients.Conclusion: Both TI and PI in the serum were correlated to Body fat distribution in OSAHS patient.

Key words: obstructive sleep apnea-hypopnea syndrome, true insulin, proinsulin, body mass index, waist circumference, neck circumference