天津医药

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卡氮芥、阿糖胞苷为主联合化疗治疗Ⅳ期非霍奇金淋巴瘤

庞华,司玉玲,綦振家,王英娟   

  1. 天津市第四中心医院
  • 收稿日期:2010-02-22 修回日期:2010-04-27 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 庞华

The chemotherapy regimen based on carmustinum and cytarabine for the treatment of NHL in stage Ⅳ

  • Received:2010-02-22 Revised:2010-04-27 Published:2010-08-15 Online:2010-08-15

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摘要： 探讨Ⅳ期非霍奇金淋巴瘤经济有效的化疗方案。方法：对心肝肾功能正常、骨髓检查增生活跃的复治的Ⅳ期非霍奇金淋巴瘤患者，应用卡氮芥（62.5-125mg/d，第1d）、阿糖胞苷（100mg/d，第1-5d）、吡柔比星（40mg/d，第1d）、长春新碱（1.5mg/d，第1、8d）和地塞米松（10mg/d，第1-14d）组成的联合化疗方案进行化疗。结果：22例患者中，完全缓解5例，部分缓解 10例，有效率 68.2%。结论：以卡氮芥和阿糖胞苷为主的联合化疗方案是Ⅳ期非霍奇金淋巴瘤经济有效的化疗方案之一。

关键词: 非霍奇金淋巴瘤, 联合化疗

Abstract: To detect the cost-effective chemotherapeutic regimen of NHL in stage Ⅳ. Methods We treated the patients with carmustinum (62.5-125mg/d，d1), cytarabine (100mg/d，d1-5),Pirarubicin （40mg/d，d1）、vincristine (1.5mg/d，d1 and d8) and dexamethasone (10mg/d, d1-14). All the patients were diagnosed NHL and in stage Ⅳ. Before chemotherapy we monitored the functions of their heart and liver and kidney and the hyperplasia degree of bone marrow. All the index above were normal. Results During all the 22 patients were identified, 5 patients obtained CR, 10 attained PR and the effective rate was 68.2%. Conclusions The chemotherapeutic regimen based on carmustinum and cytarabineis one of the cost-effective ways to treat the patients with NHL in stage Ⅳ.

Key words: Non-Hodgkin lymphoma, combined chemotherapy