天津医药

• 论著 •    

PSMA和AR在膀胱移行细胞癌中的表达及其相关性研究

杨金辉1,韩瑞发2,胡海龙3,庄士超4,白铁男4,王思成5   

  1. 1. 洛阳市中心医院
    2. 天津市泌尿外科研究所
    3. 天津医科大学第二医院；天津市泌尿外科研究所
    4. 天津医科大学第二医院
    5. 天津医科大学第二医院，天津市泌尿外科研究所
  • 收稿日期:2010-03-09 修回日期:2010-04-30 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 韩瑞发

Expression and Correlation of PSMA, AR in Bladder Transitional Cell Carcinoma

  • Received:2010-03-09 Revised:2010-04-30 Published:2010-09-15 Online:2010-09-15

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2001

摘要： 摘要 目的：研究前列腺特异性膜抗原( PSMA)、雄激素受体（AR）在膀胱移行细胞癌中的表达及其相关性，探讨其在膀胱移行细胞癌诊治中的临床意义。方法：应用免疫组织化学S-P法分别检测75例膀胱移行细胞癌组织及15例正常膀胱黏膜组织中PSMA、AR的表达情况。结果：在15例正常膀胱黏膜组织中均未见PSMA和AR的表达，而在75例膀胱移行细胞癌组织PSMA和AR的阳性表达率分别为28.0 %和21.3 %，二者与正常膀胱黏膜组织之间相比差异均具有统计学意义( P < 0.05)；PSMA的阳性表达与膀胱移行细胞癌临床分期和病理分级没有相关性，而在复发性膀胱癌患者的表达高于初发性膀胱癌患者，差异具有统计学意义(P<0.01)。；AR的阳性表达则与膀胱移行细胞癌临床分期密切相关，差异具有统计学意义( P < 0.05)。在膀胱移行细胞癌中，PSMA与AR的表达相关联(r=0.328，P<0.01)。结论：PSMA和AR能客观反映膀胱移行细胞癌的生物学行为，PSMA、AR分别对膀胱移行细胞癌的预后和肿瘤恶性程度的判断具有指导意义，二者可能在膀胱移行细胞癌的发生、发展过程中具有协同作用。

关键词: 膀胱移行细胞癌, 前列腺特异性膜抗原, 雄激素受体, 免疫组织化学

Abstract: Abstract Objective: To investigate the expression and clinical significance of PSMA and AR in bladder transitional cell carcinoma (BTCC) and their relativity. Methods: Immunohistochemistry (S-P method) was used to detect the expression of PSMA, AR in BTCC (n = 75) and normal bladder mucosa (n = 15). Results: No expression of PSMA and AR was detected in normal bladder mucosa , and the positive expression rates of PSMA and AR in 75 cases of BTCC were 28.0 %, 21.3 %, respectively. Between in BTCC and in normal bladder mucosa, the difference of the positive expression rates of PSMA, AR were both statistical significance (P < 0.05). The positive expression of PSMA was not associated with the clinical stages and pathological grade, but was associated with whether the tumor was recurrent, with the statistical analysis revealed they had significant difference (P <0.01). The positive expression rate of AR in the BTCC had a tight relationship with the clinical stage of the tumor, and there was significant difference between the two stages(P <0.05). There was a positive correlation between the expression rates of PSMA and AR (r=0.328, P<0.01). Conclusion: The expression of PSMA and AR may be regarded as important markers in biological characters and prognosis of BTCC, and they may interact with one another in the development of BTCC.

Key words: bladder transitional cell carcinoma, PSMA, AR, Immunohistochemistry