天津医药

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IgA肾病患者红细胞免疫功能测定的意义

张丽萍；闫喆；段建召；张春霞；李绍梅   

  1. 河北医科大学第二医院肾内科
  • 收稿日期:2009-10-12 修回日期:2010-05-05 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 张丽萍

Significance of Determination of Changes of red cell immune function in IgAN

  • Received:2009-10-12 Revised:2010-05-05 Published:2010-09-15 Online:2010-09-15

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摘要： 摘要目的 研讨IgA肾病红细胞免疫状态及其意义。方法 46例经肾穿刺活检明确诊断的IgA肾病，运用流式细胞仪检测红细胞膜表面CD35活性水平。结果 随着病变加重，红细胞免疫功能下降也明显，IgA肾病CD35与24小时尿蛋白定量无显著相关性，但与血清肌酐、系膜增殖程度、肾小球硬化呈正相关性(r=0.552,P<0.05，r=0.561,P<0.05，r=0.637,P<0.01，)。结论 红细胞免疫功能紊乱可能是影响IgA肾病进展的因素之一。

关键词: IgA肾病, 红细胞免疫, 蛋白尿, 肾小球硬化

Abstract: [Abstract] Objective To explore the significance of changes of red cell immune function in IgA nephropathy.. Method Forty-six type IgA nephropathy with biopsy-proven IgA nephropathy were used in this study. Flow-cytometry was applied in analysis changes of red cell of CD35 . Results: With the progress of IgA nephropathy, CD35 decreased gradually. CD35 expression did not correlate with proteinuria, but. distinctly associated with the level of serum creatinine, mesangial proliferative glomeruli and glomerulosclerosis(r=0.552,P<0.05，r=0.561,P<0.05，r=0.637,P<0.01，). Conclusion The abnormal expression of CD35 may contribute to the progression of IgA nephropathy.

Key words: IgAN, red blood cell immune, proteinuria, glomerulosclerosis