天津医药

• 论著 • 上一篇    下一篇

宫颈糜烂表现的病变特点及HPV16/18 E6的表达研究

刘丽1,尹利荣2,时杨1,马洪达3,孙俊杰4,王宇全2   

  1. 1. 天津医科大学二附属医院
    2. 天津医科大学第二医院妇科
    3. 天津医科大学第二医院
    4. 天津医大二院妇科
  • 收稿日期:2011-07-27 修回日期:2011-12-31 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 尹利荣

research about the lesion characteristics of cervical erosion performance and HPV16/18 E6 expression

  • Received:2011-07-27 Revised:2011-12-31 Published:2012-06-15 Online:2012-06-15

PDF (PC)

2294

摘要： 摘要 目的：研究肉眼拟诊为宫颈糜烂的患者其组织学诊断及人乳头瘤病毒16型（或18型）E6蛋白（HPV16/18 E6）的表达及其临床意义。方法：随机选取年龄为18--65岁的宫颈轻度糜烂组（30例）、中度糜烂组（41例）、重度糜烂组（29例），光滑组100例（对照组）。分别行阴道镜下宫颈活检，作出病理组织学诊断，采用免疫组织化学法（S-P法）测定宫颈组织中HPV16/18 E6表达情况。结果:（1）各组宫颈活检的病理结果分为: 正常、宫颈炎、CINI、CINII、CINIII及宫颈癌。CIN及宫颈癌所占比例在轻度糜烂组、中度糜烂组、重度糜烂组中逐渐升高，三组间构成比比较差异有统计学意义（P<0.05）。糜烂组与对照组比较差异有显著性（P<0.001）。 (2) E6蛋白在糜烂组中的表达高于光滑组，差异显著有统计学意义（P<0.05）。重度糜烂与轻度糜烂组之间、重度糜烂与中度糜烂组之间比较差异均有统计学意义（P<0.05），轻度糜烂组与中度糜烂组之间比较差异无统计学意义（P>0.05）。结论：肉眼拟诊为宫颈糜烂的患者其组织学诊断多样化，糜烂程度越高，发生宫颈上皮内瘤变及宫颈癌的可能性越大，HPV16/18 E6的表达水平越高。

关键词: 宫颈糜烂, 宫颈上皮内瘤变, 宫颈癌, 人乳头瘤病毒16/18型, E6蛋白

Abstract: Abstract Objective：To investigate the pathology diagnosis of the cases who were diagnosed as cervical erosion by naked eyes and the expression of human papillomavirus type 16/18 E6 protein and it’s clinical significance. Methods:Choose the age of 18-65 cervical minor erosion group (30 cases)、moderate erosion group(41 cases)、serious erosion group(29 cases),smooth group 100 cases(the contrast group).Clearring those cases’ pathology organization diagnose. The expression of human papillomavirus type 16/18 E6 protein was detected by immunohistochemistry. Results: （1）The pathology organization diagnose result of every group are：normal、cervical inflammation、CINI、CINII、CINIII and cervical cancer.The constituent ratios of cervical intraepithelial neoplasia and cervical cancer in the three groups were becoming higher and higher, the differences of consitituent ratios were statistically significant（P<0.05）. The erosion group compare with the smooth group（P<0.001）.（2）The expression of HPV16/18 E6 among the erosion groups is higher than smooth group, the differences were statistically significant（P<0.05）。Compare serious and moderate，serious and minor ,both were statistically significant（P<0.05）．Among moderate and minor, the differences were not statistically significant（P>0.05）．Conclusion: In the naked eyes imagined cervical erosion cases,their organization diagnose are diversity,more higher it’s erosion,the possibility of developing into CIN or cervical cancer is more greater,the expression level of HPV16/18 E6 is more higher.

Key words: cervical erosion, cervical intraepithelial neoplasia（CIN）, cervical cancer, human papillomavirus16/18 type, E6 protein