天津医药

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2型糖尿病8-异前列腺素F2α与脂联素基因SNP+45(T/G)多态性的相关性

徐玉善1,赵云娟1,杨慧英1,黄云超2,刘华3,李红1   

  1. 1. 昆明医学院第一附属医院
    2. 昆明医学院第三附属医院
    3. 昆明医学院第一附属医院内分泌与代谢病科
  • 收稿日期:2010-07-26 修回日期:2011-01-11 出版日期:2011-07-15 发布日期:2011-07-15
  • 通讯作者: 徐玉善

The relationship between adiponectin gene SNP+45(T/G) polymorphism and 8-isoprostaglandin F2αin T2DM.

  • Received:2010-07-26 Revised:2011-01-11 Published:2011-07-15 Online:2011-07-15

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摘要： 【摘要】目的：探讨脂联素基因SNP+45(T/G)多态性与T2DM氧化应激之间有无相关关系。方法：PCR-RFLP方法检测120例T2DM患者脂联素SNP+45(T/G)多态性。采用酶联免疫的方法检测的血清浓度，检测空腹血糖、血脂、基础胰岛素水平和HOMA-IR等指标。结果：T2DM脂联素SNP45位点GG、TG和TT基因型血清8-异前列腺素F2α浓度无统计学差异。结论：脂联素SNP+45(T/G)多态性与T2DM氧化应激之间无相关关系。

关键词: 2型糖尿病, 脂联素, 基因多态性, 8-异前列腺素F2α, 氧化应激

Abstract: Abstract Objective To investigate the relationship between adiponectin gene SNP +45 (T/G) polymorphism and oxidative stress in type 2 diabetes. Methods The SNP +45 (T/G) polymorphism of the selected 120 cases with T2DM patients was detected by PCR-RFLP. We detected serum 8-isoprostaglandinF2α concentrations by enzyme-linked immunosorbent assay method. Results There was no statistic difference of the serum 8-isoprostaglandinF2α concentration in adiponectin SNP45 site of GG, TG and TT genotype in type 2 diabetes. Conclusion There may be not significant relevance between adiponectin gene SNP +45 (T/G) polymorphism and oxidative stress in type 2 diabetes.

Key words: type 2 diabetes, adiponectin, gene polymorphism, 8-isoprostaglandinF2α, oxidative stress