• 论著 • 上一篇    下一篇

不同乙醇摄入量对心脏结构、功能及氧化应激的影响

程燕1,孙尧1,魏剑芬2,马新颖1,梁芳倩1,于晓龙1   

  1. 1. 华北煤炭医学院附属医院
    2. 河北省唐山市建设路华北煤炭医学院附属医院
  • 收稿日期:2011-01-05 修回日期:2011-03-14 出版日期:2011-07-15 发布日期:2011-07-15
  • 通讯作者: 程燕

Effects of Ethyl Alcohol Intaking Quantity on Cardiac Structure and Function and on Oxidative Stress

  • Received:2011-01-05 Revised:2011-03-14 Published:2011-07-15 Online:2011-07-15
  • Contact: Cheng-Yan

摘要: 目的:探讨不同乙醇摄入量对心脏结构和功能的影响及氧化应激在乙醇所致心肌损伤中的作用。方法:对2009年3月至2009年11月在华北煤炭医学院附属医院和唐山钢铁集团股份有限公司医院参加健康体检者进行调查。采用统一调查表进行问卷调查,符合纳入标准者共293人。调查对象按照平均每天摄入乙醇量的不同,将调查对象分为4组:小量饮酒组、中量饮酒组、大量饮酒组和不饮酒组。各组均行超声心动图检查和测定血B型尿钠肽(BNP),以检测心脏结构和功能。同时测定血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、金属硫蛋白(MT)含量等氧化应激指标。结果:1. 中、大量饮酒组与不饮酒组比较,左室收缩末期内径(LVSD)、左室舒张末期内径(LVDD)增高,血清BNP浓度升高。而左室射血分数(EF%)、左室短轴缩短率(FS%)、 E/A比值降低;大、中量饮酒组之间比较,LVSD、 LVDD增高,血清BNP浓度升高。而EF、FS、 E/A比值降低。小量饮酒组与不饮酒组之间比较,LVSD、 LVDD 、EF、FS、E/A比值及血清BNP浓度无明显变化。2. 对于血清MDA,中、大量饮酒组高于不饮酒组和小量饮酒组,大量饮酒组也高于中量饮酒组,而小量饮酒组低于不饮酒组。对于血清SOD和MT,中、大量饮酒组含量低于不饮酒组和小量饮酒组。大量饮酒组低于中量饮酒组,而小量饮酒组高于不饮酒组,差异都具有统计学意义(P<0.05)。结论:中、大量饮酒在一定程度上使心室扩张,心功能下降,而小量饮酒未对心脏结构和心功能产生影响。中、大量饮酒者机体氧化应激状态活 跃,而小量饮酒可使机体氧化应激水平下降。

关键词: 乙醇, 饮酒量, 心功能, 氧化应激

Abstract: Objective : Discussing the effects of ethyl alcohol intaking quantity on cardiac structure and function and the effects of oxidative stress on cardiac muscle damage lead by ethyl alcohol. Method: investigating the people who take the physical examination in affiliated hospital of North China Coal Medical University and the Tangshan Steel and Iron Group Limited Liability Company Hospital from March, 2009 to November, 2009. 228 people have answered the questionnaire. The respondents are divided into 4 groups according to the different ethyl alcohol quantity per day: The small quantity of alcohol group, the median quantity of alcohol group, large quantity of alcohol group and zero quantity of alcohol group. Each group takes the echocardiogram test and the determination blood B urine sodium peptide (BNP) in order to examine the cardiac structure and the function. Simultaneously determines in the blood serum the third dial (MDA), the hyperoxide mutase (SOD), the metal sulfur protein (MT) oxidized stress targets and so on. Results: 1、the left room contraction last stage inside diameter (LVSD), the left room diastole last stage inside diameter (LVDD) and the blood serum BNP density of people in large and median quantity of alcohol group improve compared to people in zero quantity of alcohol group.But the left room shoots the menstruation number (EF%), the left room minor axis contraction (FS%), the E/A ratio reduces.LVSD, LVDD and the blood serum BNP density of people in large quantity of alcohol improve compared to people in median quantity of alcohol. But EF, FS, the E/A ratio reduces .LVSD, LVDD,EF, FS, the E/A ratio and the blood serum BNP density of small quantity of alcohol do not change a lot compared to zero quantity of alcohol.2 Regarding blood serum MDA, median and large quantity of alcohol group contain higher than zero and small quantity of alcohol group. 2、Regarding blood serum MDA, median and large quantity of alcohol group contain higher than zero and small quantity of alcohol group. large quantity of alcohol group contain higher than the median quantity of alcohol group, while the small quantity of alcohol group contains lower than zero quantity of alcohol group. Regarding blood serum SOD and MT, median and large quantity of alcohol group contain lower than zero and small quantity of alcohol group. Large quantity of alcohol group contains lower than median quantity of alcohol group, while small quantity of alcohol group contains higher than zero quantity of alcohol group. The difference has statistics significance (P<0.05).Conclusion: Median and large quantity of alcohol make the ventricle expand to a certain extent, the heart function drops, while the small quantity of alcohol doesn’t have any influence to the heart structure and function. The organism oxidation stress condition of those who take large and median quantity of alcohol is active, while taking small quantity of alcohol is possible to cause organism oxidation stress level to drop.

Key words: Ethyl alcohol, quantity of alcohol, Heart function, Oxidized stress