天津医药

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病毒性肝炎患者血清铁代谢指标的临床分析

韩梅丽1,江宇泳2,于浩2   

  1. 1. 兖矿集团有限公司总医院
    2. 首都医科大学附属北京地坛医院
  • 收稿日期:2014-01-07 修回日期:2014-05-13 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 江宇泳

Analysis of the Parameters of Serum Iron Metabolism in Viral Hepatitis

  • Received:2014-01-07 Revised:2014-05-13 Published:2014-09-15 Online:2014-09-15
  • Contact: Yu-Yong JIANG

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摘要： 目的 探讨血清铁代谢指标与病毒性肝炎患者肝脏炎症活动度的关系；乙型肝炎患者与丙型肝炎血清铁代谢指标有无差异。方法 入组135例乙肝患者和31例丙型肝炎患者，收集患者血清铁（SI）、血清铁蛋白（SF）、转铁蛋白（TRF）、总铁结合力（TIBC）并计算转铁蛋白饱和度（TS），肝功能指标谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）、白蛋白（ALB）。结果 TRF、TIBC与年龄成负相关；SI、SF、TS分别与ALT、AST、TBIL有显著正相关，SF、TS与ALB成显著负相关；TRF、TIBC分别与ALT、AST、TBIL成负相关，与ALB成正相关（r=0.551，P＜0.001）。丙型肝炎患者的SF高于乙型肝炎患者，TRF及TIBC低于乙型肝炎患者（P=0.003），SI及TS在两组中无显著性差异。结论 血清铁代谢指标与肝脏炎症活动度有显著相关性； 慢性丙型肝炎与慢性乙型肝炎患者相比，铁超载现象明显。

关键词: 病毒性肝炎, 铁代谢, 肝脏炎症, 慢性丙型肝炎

Abstract:

[Abstract] Objective To investigate the relationships between parameters of serum iron metabolism and liver in? flammatory activity grades, and to find out the difference in parameters of serum iron metabolism between patients with hepa? titis B and patients with hepatitis C. Methods A total of166patients with viral hepatitis were enrolled in this study, in? cluding135case of hepatitis B and31cases of hepatitis C. The serum iron metabolism indexes including serum iron (SI), se? rum ferritin (SF), transferring (TRF), total iron binding capacity (TIBC) were collected, and the transferring saturation (TS), al? anine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and albumin (ALB) were calculated. Thirty-nine patients were selected from135hepatitis B patients by corresponding gender, age and liver function with31hep? atitis C patients. The indicators of iron metabolism were compared between two groups.Results There was a positive corre? lation between age , TRF and TIBC. There were positive correlations between SI, SF, TS and ALT, AST, TBIL respectively, and negative correlations between SF, TS and ALB. TRF and TIBC were negatively correlated with ALT, AST and TBIL, but positively correlated with ALB (rs=0.551，P＜0.001). The value of SF was significantly higher in patients with hepatitis C than that of patients with hepatitis B. The levels of TRF and TIBC were significantly lower in patients with hepatitis C than those of patients with hepatitis B (P＜0.05). There were no significant differences in SI and TS between two groups. Conclu? sion There was a significant correlation between parameters of serum iron metabolism and live inflammatory activity grades. The iron overload phenomenon is much common in patients with chronic hepatitis C than that of patients with chronic hepatitis B.

Key words: viral hepatitis, iron metabolism, liver inflammatory activity, chronic hepatitis C