天津医药

• 论著 •    

糖尿病脂肪肝患者visfatin与胰岛素抵抗关系的研究

刘聪1,邸阜生1,王璐2,贾国瑜3,杨莉2   

  1. 1. 天津市第三中心医院内分泌科
    2.
    3. 天津市第三中心医院
  • 收稿日期:2009-11-18 修回日期:2010-04-23 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 邸阜生

The Change of Plasma Visfatin Level in Type 2 Mellitus Diabetes with Nonalcoholic Fatty Liver Disease

  • Received:2009-11-18 Revised:2010-04-23 Published:2010-09-15 Online:2010-09-15

PDF (PC)

1837

摘要： 目的：探讨2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者血浆visfatin水平变化及其与其它代谢、生化指标的关系。 方法：采用酶联免疫吸附法（ELISA）检测了T2DM合并NAFLD组(1组)、T2DM不合并NAFLD组（2组）以及正常对照组（3组）的血浆visfatin水平，同时测定各组血糖、血脂、糖化血红蛋白、空腹胰岛素水平，计算腰臀比（WHR）、体质量指数（BMI），稳态模型胰岛素抵抗指数（HOMA-IR），分析上述各指标与visfatin的关系。 结果：（1）1组和2组的血浆visfatin水平均显著高于3组(P<0.01,P<0.05)；（2）直线相关分析显示，1组血浆visfatin水平与HOMA-IR、 FIns、P2hBG呈正相关(r分别为0.409、0.344、0.448，P<0.01), 2组血浆visfatin水平与HOMA-IR、 FIns、FBG、P2hBG、LDL呈正相关(r分别为0.704、0.520、0.453、0.362、0.314,P<0.05)。（3）多元逐步回归分析表明HOMA-IR、P2hBG、LDL分别是影响血浆visfatin水平的独立因素。结论：血浆visfatin水平与机体的胰岛素敏感性有关，并可能通过这一机制影响T2DM及NAFLD的发生发展。

关键词: visfatin, 糖尿病, 2型, 非酒精性脂肪性肝病

Abstract: Objective: To investigate the relationship between changes of the plasma visfatin level and the other indexes of metabolic and biochemery in type 2 diabetes mellitus with or without nonalcoholic fatty liver disease.Methods: Plasma visfatin level were assayed by ELISA in all subjects.The relationship of plasma visfatin level with blood glucose、blood lipids、HbA1c、FINs、WHR、BMI、HOMA-IR were also analyzed. Results: Plasma visfatin level in the two groups of type 2 were significantly increased compared with controls. Plasma visfatin level was positively correlated with HOMA-IR、Fins、P2hBG and was positively correlated with HOMA-IR、Fins、FBG、 P2hBG、LDL.Multiple regression analysis showed that HOMA-IR、P2hBG、LDLwere independent related fators in influencing plasma visfatin level.Multiple regression analysis showed that HOMA-IR、P2hBG、LDL were independent related fators in influencing plasma visfatin level .Conclusion: The change of plasma visfatin level is associated with the sensitivity of insulin,which may contribute in part to the pathogenesis of type 2 diabete mellitus and nonalcoholic fatty liver disease.

Key words: visfatin, mellitus diabetes, type 2, nonalcoholic fatty liver disease