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2型糖尿病周围神经病变与代谢综合征相关性探讨

宋秀霞   

  1. 首都医科大学附属医院北京世纪坛医院
  • 收稿日期:2011-08-01 修回日期:2011-12-15 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 宋秀霞

A Study on Relationship of Metabolic Syndrome with Diabetic Peripheral Neuropathy in Type 2 Diabetes Patients

  • Received:2011-08-01 Revised:2011-12-15 Published:2012-07-15 Online:2012-07-15

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摘要： 目的：探讨2型糖尿病合并糖尿病周围神经病变与代谢综合征(MS)的相关性。方法：对302例2型糖尿病患者完成Michigan糖尿病神经病变症状评分和Michigan体征评分及神经电生理检查，同时进行代谢综合征组分（腰围、血糖、血脂、血压）测定，比较上述神经病变指标在MS组与非MS组间差异性。结果：糖尿病合并MS组周围神经患病率（57.5%）、神经症状积分（4.12±1.89）和体征积分（2.15±1.60）较非MS组（44.3%，1.69±1.54，1.56±1.01）增高，差异有统计学意义（P<0.05），腓总感觉神经(左侧43.7±4.6m/s，右侧40.0±4.9m/s)及左正中感觉神经传导速度（51.7±4.2m/s）较非MS组(左腓神经46.1±4.0m/s，右腓神经45.9±4.5m/s，左正中神经55.5±4.3m/s)减慢，差异有统计学意义（P<0.05）。多因素回归分析显示，在校正了性别、年龄、病程、血糖、血压等因素后，代谢综合征仍与神经病变发生独立相关，OR值为1.195，P<0.05。结论：代谢综合征与2型糖尿病患者周围神经病变的发生密切相关。

关键词: 2型糖尿病, 代谢综合征, 周围神经病变

Abstract: Objective: To research the relationship between peripheral neuropathy and Metabolic Syndrome (MS) in 2 type diabetes. Methods: 302 type 2 diabetes patients Were examined by Michigan diabetic neuropathy score and nerve electrophysiological test. Patients were divided into 2 groups according to their blood pressure, glucose levels, blood lipids and waistlines. Results: In the metabolic syndrome group, the prevalence of peripheral neuropathy (57.5%)and Michigan diabetic neuropathy symptom score(4.12±1.89) and sign score(2.15±1.60) were higher than those in non-MS group(44.3%，1.69±1.54，1.56±1.01)(all P<0.05). Peroneal sensory nerve conduction velocity (43.7±4.6m/s in left， 40.0±4.9m/s in right) in MS group were lower than those in non-MS group(46.1±4.0m/s in left， 45.9±4.5m/s in right).The left median sensory nerve conduction velocity(51.7±4.2m/s) in MS group was lower than that of non-MS group(55.5±4.3m/s) (all P<0.05).Multiple regression analysis show that MS was independently related to peripheral neuropathy after adjustment for sex, age, disease duration, blood pressure and blood glucose. OR value was 1.195, P<0.05. Conclusion: Metablic syndrome may be related to the progress of diabetic peripheral neuropathy in type 2 diabetes.

Key words: Metabolic Syndrome, Type 2 Diabetes, Peripheral neuropathy