天津医药

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MMP-3基因多态性对冠状动脉介入术后再狭窄的影响

陈闽荔1,杜纪兵2,刘寅1,高静1,崔让庄1,陈树涛1,丛洪良3   

  1. 1. 天津市胸科医院心内科
    2. 天津市胸科医院CICU科
    3. 天津胸科医院心内科
  • 收稿日期:2013-02-20 修回日期:2013-07-09 出版日期:2013-11-15 发布日期:2013-11-15
  • 通讯作者: 杜纪兵

Effects of MMP-3Gene Polymorphism in Restenosis after Percutaneous Coronary Interventions

CHEN Min li,DU Ji bing,LIU Yin ,GAO Jing ,CUI Rang zhuang,CHEN Shu tao,CONG Hong liang   

  1. Tianjin Chest Hospital
  • Received:2013-02-20 Revised:2013-07-09 Published:2013-11-15 Online:2013-11-15
  • Contact: DU Ji bing

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摘要：

【摘要】 目的  探讨基质金属蛋白酶-3（MMP-3）启动子区域5A/6A基因多态性是否参与了经皮冠状动脉介入治疗（PCI）术后再狭窄发生发展过程。   方法   入选行PCI治疗术后复查的冠状动脉造影患者437例。收集患者复查冠状动脉造影前、后临床资料及造影结果，并留取血标本进行血清MMP-3含量以及基因多态性分析。根据MMP-3基因表型不同，分为突变组（5A/5A+5A/6A，n=136）和野生组（6A/6A，n=301）。比较2组相关资料，分析基因多态性与再狭窄的关系。  结果   2组再狭窄率差异无统计学意义（42.2%vs33.1%，P＞0.05）。与突变组比较，野生组再狭窄程度[ （56.28±11.10）%vs   （36.00±10.17）%]较高（P＜0.01）；2组血清MMP-3含量[ （13.38±3.00）μg/Lvs（12.33±2.96）μg/L]
差异无统计学意义（P＞0.05）。携带6A等位基因患者再狭窄率要高于携带5A等位基因患者（P＜0.05）。携带野生基因型是PCI术后再狭窄的危险因素。  结论  携带6A等位基因患者再狭窄风险性明显高于携带5A等位基因患者

关键词: 基质金属蛋白酶－3, 多态现象, 遗传, 血管成形术, 经腔, 经皮冠状动脉, 冠状动脉再狭窄

Abstract:

[Abstract]   Objective   To investigate the relationship between matrix metalloproteinase-3(MMP-3) gene promoter
polymorphisms5A/6A and the restenosis after percutaneous coronary intervention (PCI).    Methods  A total of 437 patients with PCI were selected in this study. Patients were divided into mutant genotype group (5A/5A+5A/6A,n=136) and wild genotype group (6A/6A,n=301) according to MMP-3polymorphism. The angiography and clinic data were collected before and after coronary angiography in two groups of patients. The serum level MMP-3and genotype analysis were compared between two groups.    Results  There was no significant difference in the restenosis rate between two groups (42.2%vs33.1%,P＞0.05). The restenosis degree was significantly higher in wild genotype group than that in mutant genotype group (56.28%±11.10%vs36.00%±10.17%,P＜0.01). There was no significant difference in the serum level of MMP-3between two groups(13.38μg/L ±3.00μg/Lvs12.33μg/L±2.96μg/L,P＞0.05). There was a higher restenosis rate in patients carrying 6A allele than that of patients carrying 5A allele (P＜0.05). Carrying wild genotypes are risk factors for restenosis after PCI.   Conclusion   Patients carrying6A allele have significantly higher risk of resteonsis than patients carrying5A allele

Key words: matrix metalloproteinase-3, polymorphism, genetic, angioplasty, transluminal, percutaneous coronary, coronary restenosis