天津医药

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TFF3和SDF-1在甲状腺乳头状癌中的表达及临床意义

张小俊1,黄静2,薛刚3,张静2,张文静1,吴靖芳1   

  1. 1. 河北北方学院组胚教研室
    2. 河北北方学院
    3. 河北北方学院鼻咽喉头颈外科
  • 收稿日期:2013-01-24 修回日期:2013-05-19 出版日期:2013-09-15 发布日期:2013-09-15
  • 通讯作者: 吴靖芳

Expression and Clinical Significance of TFF3and SDF-1Proteins in Papillary Thyroid Carcinoma

ZHANG Xiao jun1,HUANG Jing 2,XUE Gang 3,ZHANG Jing 1,ZHANG Wen jing1,WU Jing fang1   

  1. 1. Department of Histology and Embryology,Hebei North University
    2. Department of Clinical Medicine,Hebei North University
    3. Department of Otolaryngology-Head and Neck Surgery, Hebei North University
  • Received:2013-01-24 Revised:2013-05-19 Published:2013-09-15 Online:2013-09-15
  • Contact: WU Jing fang

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摘要：

【摘要】  目的   分析三叶因子3(TFF3)、基质细胞诱导因子-1(SDF-1)在甲状腺乳头状癌（PTC）和癌旁组织中的表达及意义，为临床诊断PTC及评估患者预后提供依据。方法 采用免疫组织化学染色，检测并比较PTC组织芯片中癌与癌旁组织TFF3、SDF-1蛋白的表达，并分析二者的表达与临床病理特征的关系。结果 （1）PTC中TFF3阳性率和表达水平明显高于癌旁组织，在有淋巴结转移患者明显高于无淋巴结转移患者，临床Ⅲ~Ⅳ期PTC患者高于Ⅰ~Ⅱ期患者（P<0.05）。（2）PTC中SDF-1的阳性率及表达水平明显高于癌旁组织，有淋巴结转移患者明显高于无淋巴结转移患者，临床Ⅲ~Ⅳ期患者高于Ⅰ~Ⅱ患者；45岁以上患者明显高于≤45岁者（P<0.05）。（3）PTC中TFF3与SDF-1蛋白表达水平呈正相关(rs=0.266，P<0.05)。结论  TFF3和SDF-1在PTC中的高表达与癌的发生发展有关，对判断PTC的恶性程度和病情进展有重要价值。

关键词: 甲状腺肿瘤, 癌, 乳头状, 免疫组织化学, 三叶因子3, 基质细胞诱导因子-1

Abstract:

[Abstract]   Objective   To investigate the expression and significance of trefoil factor3(TFF3) and stromal cell de-
rived factor-1(SDF-1) in papillary thyroid carcinoma (PTC) and adjacent tissues, and to provide the basis for clinical diagnosis and prognosis evaluation.  Methods   The expressions of TFF3and SDF-1proteins in PTC and adjacent tissues were detected by immunohistochemical SP method. The relationship between expressions of TFF3, SDF-1and clinicopathological features was analyzed.   Results   (1) The positive rate and the expression level of TFF3protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stage Ⅲ/Ⅳ than those in patients of stageⅠ/Ⅱ(P<0.05). The strong positive rate of TFF3protein in stage Ⅲ/Ⅳof PTC patients was higher than that in stageⅠ/Ⅱ（P<0.01）. (2) The positive rate and the expression level of SDF-1protein were significantly higher in PTC than those in adjacent tissues, which were higher in patients with lymph node metastasis than those in patients without lymph nodes metastasis, and were higher in PTC patients of stage Ⅲ/Ⅳ than those in patients of stageⅠ/Ⅱ, and were significantly higher in patients over45years old than those of patients ≤45years old (P<0.05). (3) There was a positive correlation between expression levels of TFF3and SDF-1proteins in PTC (r=0.266，P<0.05).   Conclusion   The higher expressions of TFF3and SDF-1in PTC were closely correlated with carcinogenesis and progression, which may play a significant value in judging the malignant degree and progression of PTC.

Key words: Thyroid neoplasms, carcinoma, papillary, immunohistochemistry, Trefoil Factor 3, Stromal cell derived factor 1