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中性粒细胞相关载脂蛋白表达与胃癌进展、转移及预后的关系

厉金雷,胡礼,余震,王蓉蓉,张行   

  1. 温州医学院附属第一医院
  • 收稿日期:2010-04-22 修回日期:2010-06-07 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 余震

The Correlation of NGAL Expression in Gastric Carcinoma with Clinicopathologic Progress , Metastasis and Prognosis

  • Received:2010-04-22 Revised:2010-06-07 Published:2010-11-15 Online:2010-11-15

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摘要： 摘要 目的：探讨中性粒细胞相关载脂蛋白（NGAL）在胃癌组织中的表达及与胃癌进展、转移及预后的关系。方法：应用免疫组化法检测NGAL在102例胃癌，32例正常胃组织中的表达，分析其与胃癌临床病理特征及预后的关系。 结果：NGAL在胃癌组织中的阳性表达率为56.9％，明显高于在正常胃组织中的21.9％（χ2=11.938，P <0.01），不同胃癌组织学分型患者NGAL阳性表达差异有统计学意义（χ2=10.180，P <0.05），NGAL表达与浆膜侵犯、TNM分期、淋巴结转移以及T分期（rs分别为0.307、0.211、0.220、0.201,P <0.05或P <0.01）呈正相关。NGAL表达阳性组和阴性组5年累积生存率分别为24.3%和43.7%，差异有统计学意义（P =0.018）。结论：NGAL在胃癌中表达上调，与胃癌进展和淋巴结转移显著相关，提示预后不良，可作为评价胃癌预后新的生物学指标。

关键词: 中性白细胞, 载脂蛋白类, 胃肿瘤, 癌, 淋巴转移, 预后, 免疫组织化学

Abstract: Abstract Objective: To investigate the expression of neutrophil gelatinase-associated lipocalin (NGAL) in gastric carcinoma and evaluate the correlation of NGAL expression with clinicopathologic progression , metastasis and prognosis. Methods：The expression of NGAL was observed in 102 gastric carcinoma tissues and 32 normal gastic tissues by immunohistochemistry. The correlation of NGAL expression with clinicopathological parameters and metastasis was analyzed. Results： The positive rate of NGAL expression in gastric carcinoma was 56.9%, which was significantly higher than in normal gastric tissue 21.9% (χ2=11.938, P <0.01). The expression of NGAL was significantly different in Patients with different histological types (χ2=10.180, P <0.05) .The expression of NGAL was observed to correlate positively with serosal invasion, TNM stage, lymph node status and T stage(rs =0.307, 0.211, 0.220, 0.201, P <0.01 or P <0.05). NGAL expression of positive and nagative groups of five-years cumulative survival rates were 24.3% and 43.7%. Kaplan-Meier curves showed a significant difference (P =0.018).Conclusion: NGAL expression of positive in gastric carcinoma, was correlated significantly with tumor progression and lymphatic metastasis, NGAL might be a poor prognostic factor for human gastric carcinoma, and also might be a novel molecular marker to predicate the prognosis of gastric carcinoma.

Key words: neutrophils, apolipoproteins, stomach neoplasms, carcinoma, lymphatic metastasis, prognosis immunohistochemistry, 免疫组织化学