天津医药

• 论著 •    

活体肾移植供者肾小球滤过率与受者移植肾功能关系的研究

赵杰1,宋文利2,莫春柏2,王智平2   

  1. 1. 天津市第一中心医院
    2. 天津市第一中心医院移植外科
  • 收稿日期:2011-03-15 修回日期:2011-06-02 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 赵杰

The preliminary study of relationship between donor glomerular filtration rate and post-transplant graft function in living kidney transplantation

  • Received:2011-03-15 Revised:2011-06-02 Published:2012-01-15 Online:2012-01-15

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摘要： 摘要： 目的：探讨活体肾移植中供者术前肾小球滤过率（glomerular filtration rate GFR与受者移植肾功能之间的关系 方法：回顾性分析125例活体肾移植（无急性排斥反应、无移植肾功能延迟恢复、随访满2年），采用相关方法分析供者术前肾小球滤过率和受者术后1周、1年、2年肾小球滤过率之间的关系。采用多元线性回归方法分析影响受者术后1年GFR的因素。 结果：供者GFR与受者术后1周GFR相关（r=0.217 p=0.015），与术后1年的GFR相关（r=0.216 p=0.015）。供者GFR与受者术后2年的GFR相关（r=0.273 p=0.003） 。 根据多元线性回归分析得出供者GFR和受者体重是受者术后1年GFR重要的预测因素，线性回归方程：受者术后1年GFR=79.9－0.49×受者体重＋0.24×供者GFR。 结论：活体肾移植供者术前GFR为移植肾功能的重要预测因素。

关键词: 肾移植, 活体供者, 移植肾功能, 肾小球滤过率

Abstract: Abstract: Objective: To investigate the relationship between donor glomerular filtration rate and post-transplant graft function in living kidney transplantation Methods: A retrospective analysis of 125 cases of living donor kidney transplantation (without acute rejection or delayed graft function, follow-up for 2 years) ,donor estimated glomerular filtration rate ,recipient estimated glomerular filtration rate at 1week and1 ,2 years post transplantation. Using the correlation method to analyze the relationship between them. Using multiple linear regression analysis of he relationship between donor weight, donor age, donor GFR, recipient age, recipient weight and recipient GFR at 1 year post transplantation . Results: The GFR of recipients at 1week,1 ,2 years post transplantation were significant correlated with the donor GFR(r=0.217 p=0.015,p = 0.039 and p = 0.003 respectively ). According to multiple stepwise regression analysis, donor GFR and recipient body weight were predictors of grft function at 1 year post transplantation, the linear regression equation : recipient GFR at 1 year post transplantation=79.9－0.49×recipient body weight＋0.24×donor GFR。 Conclusion: The donor GFR was the important characteristic for predicting the grft function in living kidney transplantation

Key words: kidney transplantation, donor, graft function, GFR