天津医药

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HBeAg在肝衰竭和慢乙型肝炎中的表达

于芳芳,曹武奎,李秋伟,闫妍   

  1. 天津市传染病医院
  • 收稿日期:2011-03-02 修回日期:2011-08-07 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 于芳芳

The expression and significance of HBeAg in liver failure and chronic hepatitis B

  • Received:2011-03-02 Revised:2011-08-07 Published:2012-01-15 Online:2012-01-15
  • Contact: fang-fang YU

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摘要： 摘要 目的：研究慢性乙型肝炎和肝衰竭患者HBeAg的表达及其与血清中HBV-DNA的关系。方法：收集天津市传染病医院2007年4月—2010年9月收治的118例慢性乙型肝炎患者和109例肝衰竭患者确诊时的相关资料，分析2组患者HBV-DNA含量的变化、HBeAg阳性和阴性的比例，以及HBeAg阳性和阴性患者的HBV-DNA含量的变化。结果：肝衰竭组HBeAg阴性患者所占比例较慢性乙型肝炎组高，且HBeAg阴性组HBV-DNA水平较阳性组低；与慢性乙型肝炎组相比，肝衰竭组HBV-DNA水平较低，HBeAg阳性和阴性的肝衰竭患者HBV-DNA水平均低于相应的慢性乙型肝炎组患者；肝衰竭组内HBeAg阴性所占比例差异无统计学意义，慢性肝衰竭和慢加急性（亚急性）肝衰竭早期组患者的HBV-DNA水平低于慢加急性（亚急性）肝衰竭晚期组，而慢加急性（亚急性）肝衰竭中、晚期患者HBV-DNA水平无统计学差异。结论：HBeAg的不同表达在肝衰竭和慢性乙型肝炎病情演变过程中可能起着重要作用，但不影响病情的轻重。

关键词: HBeAg阴性, HBV-DNA, 肝衰竭, 慢乙肝

Abstract: Abstract Objective: To explore the expression of HBeAg and the relationship of HBeAg and serum HBV-DNA in chronic hepatitis B and liver failure. Methods: we collected 118 patients with Chronic Hepatitis B (CHB) and 109 patients with liver failure from Tianjin Infectious Diseases Hospital in April 2007 to September 2010，and analyzed retrospectively the changes of HBV-DNA content, the proportion of HBeAg-positive and-negative patients and the HBV-DNA content changes of HBeAg-positive and-negative patients .Results:in liver failure group the proportion of HBeAg-negative patients is higher than the proportion of CHB group, and the HBV-DNA level of HBeAg-negative patients is lower than the positive; the HBV-DNA level of liver failure group is lower than CHB group, and the HBVDNA levels of HBeAg positive and negative patients with liver failure are lower than the corresponding group of patients with CHB; In liver failure group, the proportions of HBeAg-negative patients are no significant difference , the HBV-DNA levels of patients whit Chronic liver failure and early acute-on-chronic liver failure are lower than the late acute-on-chronic liver failure ,but the HBV-DNA level of medium and late acute-on-chronic liver failure is no significant difference. Conclusion: different expression of HBeAg may play an important role in the evolution of chronic hepatitis B and liver failure, but it does not related with the severity of illness.

Key words: HBeAg-negative, HBV-DNA, liver failure, CHB