天津医药

• 论著 •    

CD147和MMP-2在宫颈癌中的表达及其意义

徐雅会1,王德华2   

  1. 1. 天津市静海县医院
    2. 天津医科大学总医院
  • 收稿日期:2009-11-16 修回日期:2009-12-09 出版日期:2010-04-15 发布日期:2010-04-15
  • 通讯作者: 徐雅会

The Expression and Clinical Significance of CD147 and MMP-2 in Cervical Cancer

  • Received:2009-11-16 Revised:2009-12-09 Published:2010-04-15 Online:2010-04-15
  • Contact: XU Ya-Hui

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摘要： 摘要:目的: 探讨宫颈上皮内瘤样变(CIN)及宫颈癌中CD147和MMP-2的表达及其意义。方法： 采用免疫组化S-P法检测20例正常宫颈组织、21例CIN组织、59例宫颈癌组织中CD147和MMP-2的表达情况并加以分析。结果：1. CD147和MMP-2主要在肿瘤组织中表达，在正常组织中也有表达。宫颈癌组织中CD147和MMP-2表达明显高于正常宫颈组与CIN组(P<0.05)，其阳性率分别为91.5%和80.0%。2.宫颈癌中，CD147表达与淋巴结转移有关 (χ2=4.138，P<0.05)，与年龄、临床分期、大体类型、分化程度、组织类型均无关(P>0.05)；MMP-2表达与临床分期 (χ2=9.423，P<0.05)及淋巴结转移 (χ2=5.019，P<0.05)有关；与年龄、大体类型、分化程度、组织类型均无关(P>0.05)。3. 宫颈癌组织中CD147与MMP-2之间呈正相关(P<0.05)。结论： CD147和MMP-2在宫颈癌的浸润和转移方面起重要作用，联合检测CD147和MMP-2成为宫颈癌诊断的标志物,是评估宫颈癌严重程度的新指标。

关键词: 宫颈癌, 宫颈上皮内瘤, CD147, MMP-2, 免疫组织化学免疫组织化学

Abstract: The Expression and Clinical Significance of CD147 and MMP-2 in Cervical Cancer Xu Ya-hui, Wang De-hua Tianjin Medical Unervisity General Hospital. [Abstract] Objective : To study The Expression and Clinical Significanceof CD147 and MMP-2 in Cervical Cancer. Methods Using immunohistochemical SP method to detec t and analysis the expression of CD147 and MMP-2 in 20 cases of normal cervical tissue，21 cases of CIN tissue，59 cases of cervical cancer .Results 1.CD147 and MMP-2 were expressed mainly in cancerous lesions，but also expressed in some normal tissues. The expression of CD147 and MMP-2 in cancer group was significantly higher than the normal cervical group and CIN group(P<0.05). Positive expression rate of them were 91.5%和80.0%.2 Expression of CD147 in cervical cancer were related with lymphatic matastasis(χ2=4.138，P<0.05), not related with age，stage，gross type，the degree of differentiation，histological types (P> 0.05). Expression of MMP-2 were related with stage(χ2=9.423，P<0.05) and lymphatic matastasis (χ2=5.019，P<0.05), not related with age，gross type，the degree of differentiation，histological types(P> 0.05). 3. The relationship between CD147 and MMP-2 was positively correlated，and the correlation coefficient rs = 0.283 (P<0.05). Conclusion CD147 and MMP-2 plays an important role in cervical cancer invasion and metastasis，Combined detection of CD147 and MMP-2 may be a new target of cancer diagnosis to assess the severity of cervical cancer.

Key words: Cervical carcinoma, Cervical intraepithelial neoplasia, CD147, MMP-2, Immunohistochemistry