天津医药

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ATGL与2型糖尿病非酒精性脂肪肝相关性的初步研究

洪燕青   

  1. 天津市第三中心医院
  • 收稿日期:2009-11-13 修回日期:2009-12-10 出版日期:2010-09-15 发布日期:2010-09-15
  • 通讯作者: 洪燕青

The Initial Study of Relationship between ATGL and Type 2 diabetes mellitus With Non-alcoholic Fatty Liver

  • Received:2009-11-13 Revised:2009-12-10 Published:2010-09-15 Online:2010-09-15

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摘要： 目的: 探讨脂肪组织三酰甘油脂肪酶（ATGL）与2型糖尿病（T2DM）非酒精性脂肪肝（NAFLD）相关代谢指标的关系。方法: 采用酶联免疫吸附法 (ELISA)测定131例初发T2DM患者即T2DM组(不合并脂肪肝者74例为A组；合并脂肪肝者57例为B组)与44例正常对照者组(NC组)空腹血浆ATGL水平，在A组、B组、NC三组之间比较各基线资料和血浆ATGL的水平，分析各基线资料与血浆ATGL的相关性，并对各变量进行多元逐步回归分析。结果: A组的空腹血浆ATGL显著低于NC组[(39.13?23.98)ng/mL vs (69.21?27.05) ng/mL，P<0.01]；B组的空腹血浆ATGL显著低于NC组[(18.25?14.85)ng/mL vs (69.21?27.05) ng/mL，P<0.01]；B组空腹血浆ATGL低于A组[(18.25?14.85) ng/mL vs(39.13?23.98) ng/mL，P<0.01]。2型糖尿病患者血浆ATGL水平与TC、TG、Fins、BMI 、HOMA-IR呈负相关（r分别为-0. 222 、-0.424、-0.317、-0.200、-0.178，均P<0.05）。多元逐步回归分析显示Fins、BMI、TC是血浆ATGL水平的影响因素。结论: ATGL可能影响T2DM患者非酒精性脂肪肝的发生发展。

关键词: 脂肪组织三酰甘油脂肪酶, 非酒精性脂肪肝, 2型糖尿病

Abstract: Objective: To explore the relationship between plasma ATGL and related metabolic indexes of Type 2 diabetes mellitus with fatty liver. Methods: Fasting plasma ATGL level of one hundred and thirty-one patients with incipient T2DM,T2DM group (seventy four patients without fatty liver, A group; fifty seven patients with fatty liver, B group) and forty four healthy subjects (NC group)were assayed by enzyme-linked immunosorbent asssy(ELISA),A comparison about basal materials and ATGL was made between A group 、B group and NC group, correlation of ATGL and basal materials were measured as well, then multiple stepwise regression analysis were made. Results: Fasting plasma ATGL level in T2DM without fatty liver was significantly lower than controls（P<0.01）,39.13?23.98ng/ml vs 69.21?27.05 ng/ml. Fasting plasma ATGL level in T2DM with fatty liver was significantly lower than controls（P<0.01）,18.25?14.85ng/ml vs 69.21?27.05 ng/ml. Fasting plasma ATGL level in T2DM with fatty liver was significantly lower than without fatty liver（P<0.01）,18.25?14.85 ng/ml vs 39.13?23.98 ng/ml. Correlation analysis showed that the fasting ATGL level was negatively in correlation with TC、TG、、Fins 、BMI、HOMA-IR（r=-0. 222 、-0.424、-0.317、-0.200、-0.178，P<0.05）. Multiple stepwise regression analysis showed that Fins、BMI、TC were independent related factors that influenced the level of plasma ATGL. Conclusion: ATGL may contribute to the pathogenesis of T2DM with non-alcoholic fatty liver.

Key words: ATGL, Non-alcoholic fatty liver, Type 2 diabetes mellitus