天津医药

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中国人群TGFβ1基因多态性与乙型肝炎肝硬化关系的Meta分析

薛敏敏1,徐忠良2,董公明3,谢芳1,吴佩群1,白岚1   

  1. 1. 南方医科大学南方医院
    2. 天津市疾病预防控制中心
    3. 天津医科大学附属肿瘤医院
  • 收稿日期:2013-08-16 修回日期:2014-01-03 出版日期:2014-05-15 发布日期:2014-05-15
  • 通讯作者: 薛敏敏

Relationship between TGFβ1 gene polymorphism and liver cirrhosis after hepatitis B virus infection: A meta-analysis in Chinese population

  • Received:2013-08-16 Revised:2014-01-03 Published:2014-05-15 Online:2014-05-15
  • Contact: Minmin XUE

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摘要： 目的 探索转化生长因子（Transforming growth factor β1, TGFβ1）基因多态性与我国人群乙型肝炎肝硬化的关系。方法 计算机检索中国生物医学文献数据库、重庆维普中文科技期刊全文数据库，清华CNKI数据库、万方科技期刊全文数据库、Pubmed，检索时间范围为建库到2013年7月。按纳入、排除标准选择TGFβ1基因509位点、869位点基因多态性与乙型肝炎肝硬化关系的病例对照研究。应用RevMan 5.1软件对纳入的研究进行定量分析。结果 共纳入6个病例对照研究。Meta分析结果显示509位点携带T等位基因的乙型肝炎肝硬化的合并OR值为1.02，95%CI为（0.67~1.54），CT和TT基因型者乙型肝炎肝硬化的合并OR值为0.80，95%CI为（0.36~1.78）；869位点携带C等位基因的乙型肝炎肝硬化的合并OR值为1.05，95%CI为（0.69~1.62），TC和CC基因型者乙型肝炎肝硬化的合并OR值为0.98，95%CI为（0.48~2.00）。未发现显著发表偏倚。结论 未发现中国人群中TGFβ1 基因多态性与乙型肝炎肝硬化有联系。

关键词: 乙型肝炎肝硬化, 转化生长因子基因多态性, Meta分析

Abstract: Objective To evaluate the relationship between genetic polymorphism of transforming growth factorβ1 (TGFβ1) and susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population. Methods CBM, VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to July, 2013 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF β1 promoter 509 site, codon 869 site and liver cirrhosis after hepatitis B virus infection. The data were quantitatively analyzed by RevMan 5.1 software after assessing the quality of included studies. Results 6 case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of meta-analysis showed that the pooled OR value for liver cirrhosis among Chinese patients after hepatitis B virus infection with T allele of TGFβ1 gene at promoter 509 was 1.02 (95％CI: 0.67~1.54), the pooled OR values for patients with TT and CT genotype were 0.80 (95％CI: 0.36~1.78); Patients with C allele of TGFβ1 gene at codon 869 was 1.05 (95％CI: 0.69~1.62), the pooled OR values for patients with CC and CT genotype were 0.98 (95％CI: 0.48~2.00). No significant publication bias was found. Conclusion The genetic polymorphism of TGFβ1 at promoter 509 and codon 869 shows no association with susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population.

Key words: liver cirrhosis, genetic polymorphism of transforming growth factor β1, meta-analysis