天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (3): 309-316.doi: 10.11958/20190037

• 循证医学 • 上一篇    下一篇

干细胞移植治疗缺血性脑卒中患者临床疗效的Meta分析

褚玉茹，于乃浩，阚建英   

  1. 天津市中医药研究院附属医院（邮编300120）
  • 收稿日期:2019-01-07 修回日期:2019-03-05 出版日期:2019-03-15 发布日期:2019-04-24
  • 通讯作者: 褚玉茹 E-mail:chuyuru2018@126.com

Meta analysis of clinical efficacy of stem cell therapies for patients with ischemic stroke

CHU Yu-ru,YU Nai-hao,KAN Jian-ying   

  1. Department of Emergency, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • Received:2019-01-07 Revised:2019-03-05 Published:2019-03-15 Online:2019-04-24

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摘要： 目的 对干细胞移植治疗脑卒中患者的临床疗效和安全性进行Meta分析。方法 计算机检索PubMed、EMbase、Cochrane Library、维普数据库、万方数据库及CNKI数据库有关干细胞移植治疗脑卒中患者的随机对照试验，检索时间为建库至2018年12月。经过两名系统评价员根据文献纳入与排除标准筛选文献，并提取资料中的相关重要信息，评价纳入文献的偏倚风险后，采用Stata 11.0软件进行纳入文献的Meta分析以及森林图的解析，同时绘制漏斗图及进行纳入文献的敏感性分析。结果 通过系统筛选共纳入29篇临床研究，总计1 908例脑卒中患者。干细胞移植治疗脑卒中患者神经功能缺损评分（NIHSS）、日常生活能力评定 Barthel 指数（BI）、肢体运动功能评分（FMA）和功能独立性评定量表（FIM）合并后的结果均优于对照组，2组间效应量差异有统计学意义。结论 干细胞移植治疗脑卒中能有效改善患者的神经功能缺损，提高患者自主行为能力和肢体运动功能。

关键词: 干细胞, 移植, 脑缺血, 卒中, 随机对照试验, Meta分析

Abstract: Objective To evaluate systematically the clinical efficacy and safety of stem cell therapies for patients with ischemic stroke. Methods PubMed, EMbase, the Cochrane Library, VIP database, Wanfang database and CNKI database were searched by computer about randomized controlled trials of stem cell therapies for patients with ischemic stroke. The retrieval time was from the set up of library to December 2018. Two systematic evaluators screened the literatures according to inclusion and exclusion standards, and extracted the important information of literature. After assessing the quality of included studies, the risk of bias was analyzed by Stata 11.0 software for systematic evaluation and forest plot analysis, and obtained the funnel plot and the sensitivity analysis of included studies. Results A total of 29 case-control studies including total of 1 908 ischemic stroke patients were included in the systematic screening. The results of Meta analysis showed that the neural function deficient degree score (NIHSS), Barthel index (BI), Fugl-Meyer assessment (FMA) and the functional independence measure (FIM) are significantly better in stroke patients with treatment of stem cell transplantation than those of patients in control group. Conclusion Stem cell transplantation can improve effectively the neurological deficit, autonomous behavior ability and body movement function of patients with ischemic stroke.

Key words: stem cells, transplantation, brain ischemia, stroke, randomized controlled trial, Meta-analysisanalysis