天津医药

• 论著 •    

肺炎支原体感染和AECOPD住院率相关性

李琦,张纳新,杨春红,杨志彬,杜建民   

  1. 天津市第三中心医院
  • 收稿日期:2012-02-21 修回日期:2012-09-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 李琦

The study of correlation between the Mycoplasma pneumonia infection and acute exacerbation of chronic obstructive pulmonary disease hospitalization ratio

  • Received:2012-02-21 Revised:2012-09-01 Published:2012-12-15 Online:2012-12-15

摘要： 【摘要】 目的 探讨肺炎支原体(MP)感染和慢性阻塞性肺疾病急性加重期(AECOPD)住院率的相关性。方法 收集2010年因AECOPD住院患者298例及同期其他疾病住呼吸科患者120例，分别设定为实验组和对照组，所有入选者进行 MP抗体检测。在实验组中根据肺功能结果分为四组，同时根据MP检测结果分为MP阳性组和MP阴性组。结果 MP抗体在实验组患者中总的检出率为 22.82％，显著高于对照组(P<0．01)；在不同肺功能AECOPD患者的MP检出率分别为23.63％、23.52％、19.82％、25.81％，无统计学差异(P > 0.05)。在MP阳性组和MP阴性组之间比较发现和疾病急性加重相关的临床特点上差别无显著性。并且随着发病时间的变化实验组中MP抗体检出率有所不同。MP的检出率和AECOPD的住院率无相关性（r=0.305，P > 0.05）。结论 肺炎支原体感染为AECOPD常见原因，与疾病的严重程度无关，与发病时间有关。重视MP的流行病学特点，有助于提高治疗效果。

关键词: 关键字 肺炎支原体, 慢性阻塞性肺疾病, 急性加重

Abstract: [Abstract] Background and study objective: The aetiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) is heterogeneous and still under discussion. Serological studies have suggested that Mycoplasma pneumoniae(Mp) may play a role in acute exacerbations of COPD（AECOPD）. We want to explore the correlation between the Mp infection and AECOPD hospitalizations ratio. Methods : The presence of these Mp in Serological samples was investigated in patients with AECOPD and other kinds of respiratory infection patients using passive agglutination. The present study was retrospective study and a total of 418 serological samples from 298 AECOPD inpatients (study group) and 120 other kinds of respiratory infection patients (control group) were included. According to the lung functions of the AECOPD patients the study group were divided into four subgroup. By the results of the Mp investigation the study group was divided into Mp positive group and Mp negative group. Results: Mp seroprevalences of the study group (22.82%) were higher than in the control group (12.5%) with statistical significance (P<0.01). The seroprevalences of the sub-study group were 19.28%, 25.81％,23.63％,23.52％ respectively but without statistical significance(P>0.05).We also found that the seroprevalences was different as the time go on and also there was no correlation between AECOPD hospitalization and Mp Seroprevalences（r=0.305，P > 0.05）. There were no significant differences between these two groups divided by the Mp value in a broad spectrum of patient- and exacerbation-related clinical variables. Conclusion : We have shown that microorganisms causing acute exacerbations of COPD are not only typical bacteria but also atypical pathogens with unpredictable high rates. The seroprevalences was related with outbreak time not the severity of the disease. Pay more attention to the Mp maybe get better prognosis for most patients.

Key words: Mycoplasma pneumoniae, chronic obstructive pulmonary disease, acute exacerbation