天津医药

• 临床论丛 •    

静脉注射心律平与顿服心律平转复房颤疗效及安全性比较

郭素箴1,王彦欧2,卢成志1   

  1. 1. 天津市第一中心医院
    2. 天津医科大学一中心临床学院
  • 收稿日期:2012-04-10 修回日期:2012-10-15 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 郭素箴

The safety and efficacy comparison of intravenous propafenone and loading oral propafenone for cardioversion of atrial fibrillation

  • Received:2012-04-10 Revised:2012-10-15 Published:2012-12-15 Online:2012-12-15

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摘要： 关键词 房颤 心律平 顿服 文摘 目的 观察监测临床广泛应用的静脉输注心律平转复房颤的患者，是否能安全院外处方顿服心律平转复房颤。方法 临床入选>阵发房颤患者，随机分为两组静脉负荷量心律平组和口服负荷量心律平组，对成功转复的患者院外处方顿服心律平治疗，比较两组转复率、副作用发生率、急诊就诊率 结果两组首次顿服心律平发生副作用（8.9%vs5.7%，p>0.05）,无统计学差异.而院外顿服负荷量心律平治疗副作用发生率（8.9%vs1.25%，p<0.05），急诊就诊率（19.0%vs5%，p<0.001），据统计学差异。结论患者首次转负房颤，宜院内口服负荷量，发生副作用可及时处理，保证患者安全，即使能耐受静脉冲击量心律平转复房颤，也不能预测顿服心律平不良反应的发生。

关键词: 房颤, 心律平, 顿服

Abstract: The safety and efficacy comparison of intravenous propafenone and loading oral propafenone for cardioversion of atrial fibrillation Abstract Object To monitor Widely used the clinical observation of intravenous propafenone for cardioversion of atrial fibrillation in elderly patients, whether it is safe out of hospital serving loading oral propafenone prescription cardioversion of atrial fibrillation. Method Clinical method selected> 60 years paroxysmal atrial fibrillation were randomly divided into two groups: intravenous loading dose of propafenone and oral propafenone loading dose group, patients with successful cardioversion hospital serving loading oral propafenone therapy out hospital . Prescription were compared cardioversion rate, incidence of side effects, the rate of emergency department visits. The results of the tow group first serving loading oral propafenone side effects (8.9% vs5.7%, p> 0.05), no statistically significant difference, while the out of hostpital treatment of side effects of propafenone loading rate (8.9% vs1.25%, p <0.05 ), emergency treatment rate (19.0% vs5%, p <0.001), according to statistically significant. Patients with atrial fibrillation in the first turn, should hospital oral loading dose, side effects can be timely manner to ensure patient safety, even if we can tolerate intravenous bolus propafenone cardioversion o f atrial fibrillation, it can not predict the loading oral service propafenone adverse reactions.

Key words: atrial fibrillation, propafenone, loading oral