天津医药

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2型糖尿病患者晨尿微量白蛋白 /肌酐与24h尿微量白蛋白相关性分析

仇海燕1,谢云2,李露荃3,韩丽萍4,冯克娜1   

  1. 1. 天津医科大学代谢病医院
    2. 天津医科大学代谢病医院5楼病房
    3. 北京理工大学
    4. 天津医大代谢病医院神经内科
  • 收稿日期:2011-04-19 修回日期:2011-09-20 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 仇海燕

Analysis on Relationship between Morning Urine Microalbuminuria/Urinare Creatinine and 24 h Urine Microalbuminuria in Type 2 Diabetes Mellitus

  • Received:2011-04-19 Revised:2011-09-20 Published:2012-03-15 Online:2012-03-15
  • Contact: Hai-Yan QIU

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摘要： 摘要 目的:研究2型糖尿病（T2DM）患者晨尿微量白蛋白/肌酐（MALB/Cr）相关危险因素及用晨尿MALB/Cr代替24 h尿MALB检测评估尿蛋白排泄的可行性。方法:收集179例T2DM患者晨尿和24 h尿，测定晨尿MALB、Cr、24 h尿MALB及其他各项生化指标，并按肌酐清除率（Ccr）分为25.66~49 mL /min、50~79 mL /min、≥80 mL /min 3组，进行各项生化指标与晨尿MALB/Cr的相关性分析。结果:晨尿MALB/Cr与年龄、体质指数（BMI）、DM病程、24h尿MALB、24小时尿蛋白（24 h尿TP）、收缩压（SBP）、舒张压（DBP）、糖尿病视网膜病变（DR）呈正相关。DM病程、SBP、DR是T2DM患者晨尿MALB/Cr的险因素。Ccr≥25.66 mL/min时，各组晨尿MALB/Cr与24 h尿MALB呈正相关。结论：晨尿MALB/Cr可代替24 h尿MALB，用于观察尿蛋白排泄情况并对2型糖尿病肾病进行检测和评估，此测定适用于尿量Ccr≥25.66 mL /min的不同Ccr的T2DM患者。

关键词: 糖尿病, 2型, 糖尿病肾病, 白蛋白类, 肌酸酐, 糖尿病视网膜病变, 白蛋白尿性

Abstract: Abstract Objective:To investigate the influential factors of morning urine microalbuminuria（MALB）/urine creatinine（Cr） and explore the feasibility of replacing 24-hour urine microalbuminuria protein （24hMALB ）monitoring by measuring morning urine MALB/ Cr in diagnosed type 2 diabetic patients. Methods :Morning urine sampales and 24-hour urine sampales were obtained from 179 type 2 diabetic patients, morning urine MALB,Cr, 24hMALB and other biochemical indicators were measured.All patients were divided into three groups according to the creatinine clearance rate（Ccr）.The correlation between MALB/Cr in morning urine and 24hMALB was analyzed.Results:① MALB/ Cr was positively correlated with age, body mass index, the duration of diabetes, 24hMALB,24-hour urine protein, systolic blood pressure , diastolic blood pressure,diabetic retinopathy. ②The duration of diabetes , systolic blood pressure , diabetic retinopathy is the independent risk factors of MALB/ Cr in morning urine of type 2 diabetes patients. ③The correlation between MALB/Cr and 24hMALB was statistical significance when Ccr≥25.66mL /min.Conclusion: Detection of MALB/Cr in morning urine can replace 24hMALB to evaluate diabetic nephropathy in type 2 diabetes patients. Morning urine MALB/Cr can be applied in population with different Ccr when Ccr≥25.66mL /min.

Key words: diabetes mellitus, type 2 diabetic nephropathies albumins creatinine diabetic retinopathy albuminuria