天津医药

• 临床论丛 •    

婴幼儿巨细胞病毒肺炎42例临床分析

王静,陶枫   

  1. 天津医科大学总医院
  • 收稿日期:2011-04-13 修回日期:2011-06-26 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 王静

Clinical Analysis of 42 Cases of Infantile Cytomegalovirus Pneumonia

  • Received:2011-04-13 Revised:2011-06-26 Published:2012-03-15 Online:2012-03-15

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摘要： 目的 探讨婴幼儿巨细胞病毒(CMV)肺炎的临床特点。方法 回顾性分析42例婴幼儿CMV肺炎的临床资料。结果 CMV肺炎多见于6月以内小婴儿，临床上有不同程度的发热,咳嗽,咳痰，喘息，常有不同程度的肝功能损害，合并低丙种球蛋白血症及反复下呼吸道感染、贫血、佝偻病等。静脉滴注更昔洛韦安全有效，未见严重不良反应，部分难治病例加用静脉丙种球蛋白疗效佳。结论 反复下呼吸道感染、免疫功能低下婴幼儿肺炎,尤其合并肝功能损害者应警惕CMV肺炎。更昔洛韦治疗CMV肺炎疗效好，难治者可辅以静脉丙种球蛋白治疗。

关键词: 婴幼儿, 巨细胞病毒, 肺炎.

Abstract: [Abstract] Objective To investigate the clinical features of infantile cytomegalovirus (CMV) pneumonia. Methods Retrospective analysis the clinical data of fourty-two cases infantile CMV pneumonia. Results Infants within 6 months were more common in CMV pneumonia , manifested in varying degrees of fever, cough, sputum, wheezing, often with different degrees of liver damage, combined with low agammaglobulinemia,recurrent lower respiratory tract infections, anemia, rickets and so on. Intravenous ganciclovir were safe and effective, without severe side effects. In some resistant cases intravenous gamma globulin had good effect. Conclusions Infantile pneumonia combined with recurrent lower respiratory tract infections , immunocompromised , especially those with hepatic dysfunction should be considered of CMV pneumonia. Ganciclovir is effective in the treatment of CMV pneumonia. Refractory cases supplemented with intravenous gamma globulin.

Key words: Infant, cytomegalovirus, pneumonia