天津医药

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COPD 患者血清 1,25(OH)2D3、钙水平与 FEV1的相关性研究

齐丽   

  1. 天津市泰达医院急诊科
  • 收稿日期:2012-07-26 修回日期:2013-02-01 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 齐丽

Correlation study between serum levels of 1,25(OH)2D3、calcium and FEV1 of patients with Chronic obstructive pulmonary disease

QI LI   

  • Received:2012-07-26 Revised:2013-02-01 Published:2013-07-15 Online:2013-07-15
  • Contact: QI LI

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摘要：

【摘要】 目的  分析血清1,25-二羟维生素D3[1,25(OH)2D3]、钙(Ca2+)水平与慢性阻塞性肺疾病(COPD)患者急性加重期肺功能指标的相关性。方法   对确诊COPD患者30例,采用自身对照的方法,分别于COPD急性加重期和稳定期,测定受试者血清1,25(OH)2D3、Ca2+、磷(P),同时测定动脉血气分析及肺功能指标。结果  受试者急性加重期与稳定期相比,血清1,25(OH)2D3、Ca2+、P水平明显降低。受试者急性加重期血清中1,25(OH)2D3和Ca2+水平与患者肺功能指标第1秒用力呼气流量(FEV1)占预计值百分比[FEV1(%)]呈正相关。结论 COPD患者血清1,25(OH)2D3、Ca2+水平与FEV1(%)有关,对预防肺功能恶化及降低COPD患者病死率可能具有重要临床意义。 

关键词: 肺疾病, 阻塞性, 慢性病, 骨化三醇, 钙, 磷, 用力呼气量

Abstract: Abstrsct  Objective  To investigate the correlation between serum levels of 1,25dihydroxyvitaminD3(1,25(OH)2D3)、calcium(Ca2+) and FEV1 of patients with chronic obstructive pulmonary disease(COPD) patients. To explore the relationship between the above-mentioned mass and the Severity of COPD. Methods  Subjects were 30 patients with COPD to be parted as acute stage group and stable stage group. We measured the concentration of 1,25(OH)2D3 、serum Ca2+、serum phosphorus(P) in the serum of two stages. We obtained the data of blood gas analysis and pulmonary function tests. Results  The concentration of serum 1,25(OH)2D3、Ca2+ and P were significantly lower in acute stage group than in the stable stage group. The concentration of serum 1,25(OH)2D3 and Ca2+ positively correlated to FEV1（％）.Conclusion  The concentration of serum 1,25(OH)2D3 and Ca2+ were concerned with FEV1（％）,it suggests that above-mentioned mass may potentially prevent the future deterioration of pulmonary function and reduce case fatality rate.

Key words: chronic disease, Calcitriol, calcium, phosphate