天津医药

• 短篇论著 •    

HBV血清标志物在慢性肝炎急性肝衰竭中的表达

李萍1,唐克诚2,曹武奎2   

  1. 1. 天津医科大学研究生院
    2. 天津市第二人民医院， 天津市肝病研究所
  • 收稿日期:2013-02-20 修回日期:2013-05-29 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 曹武奎

The Expression and Significant of HBV-M in patients with acute-on chronic liver Failure

Ping LI,TANG KECHENG ,CAOWUKUI   

  • Received:2013-02-20 Revised:2013-05-29 Published:2013-07-15 Online:2013-07-15
  • Contact: CAOWUKUI

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摘要：

【摘要】 目的 研究慢性肝炎急性肝衰竭（ACLF）患者血清中乙型肝炎病毒（HBV）血清标志物表达方式及临床意义。 方法 选取 ACLF组 117 例， 慢性乙型肝炎（CHB）组 123 例和急性肝衰竭（ALF）组 21 例， 应用酶联免疫吸附法测定 HBeAg， 聚合酶链反应分别测定 3 组 HBeAg 阳性和阴性患者的 HBV-DNA 的含量， 比较 3 组 HBV-DNA 水平及HBeAg阴性的比例。 结果 3 组患者中， ALF 组 HBeAg阳性及阴性患者 HBV-DNA 水平低于 ACLF 组、CHB 组， ACLF组低于CHB组，差异有统计学意义。 ACLF组HBeAg阴性患者比例（46.2%）高于CHB组的 30.1%和ALF组的 42.9%（χ2=6.753，P＜ 0.05）。 结论 ACLF组HBV-DNA的低水平表达与该组中 HBeAg阴性患者的高比率具有一定的相关性。

关键词: 肝功能衰竭, 急性, 肝炎, 乙型, 慢性, DNA, 病毒, 肝炎 e抗原

Abstract: Abstract   Objective   To explore the Expression and Significant of HBV-M in patients of Acute-on-chronic liver failure（ACLF）. Methods   The data in this study were collected from 117 patients with ACLF and 123 patients with chronic hepatitis B(CHB)、21 patients with acute liver failure(ALF) were analyzed retrospectively. Results   The level of HBV-DNA in acute liver failure group was lowest and the proportion of HBeAg –negative patients in Acute-on-chronic liver failure group was highest in three groups. The level of HBV-DNA was lower and the proportion of HBeAg –negative patients was higher in ACLF group than that of CHB group, the difference were statistically significant in both(P<0．05). There are four patients with ACLF who anti–HBs、anti –HBe and anti –HBc are all positive. Three of them died. Conclusion    Patients with Acute-on-chronic liver failure is characterized by lower level of HBV-DNA and the higher proportion of HBeAg –negative patients than ALF group and CHB group. But it is not related to the severity of illness.The high antibody expression was a particular expression or it was closely related with host's invulnerability, which need further research.

Key words: hepatitis B, chronic, chronic disease, 肝炎 e抗原