天津医药

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血清凝集素样氧化低密度脂蛋白受体-1水平与急性冠脉综合征关系的研究

豆静   

  1. 天津市胸科医院
  • 收稿日期:2010-10-13 修回日期:2010-10-26 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 豆静

Correlation between serum Lectin-like Oxidized Low-density Lipoprotein Receptor-1 and Acute Coronary Syndrome

  • Received:2010-10-13 Revised:2010-10-26 Published:2011-01-15 Online:2011-01-15

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摘要： 目的 探讨血清中凝集素样氧化低密度脂蛋白受体-1(LOX-1)水平与急性冠脉综合征（ACS）的关系。方法 经冠状动脉造影（CAG）确诊的冠心病患者121例，其中ACS患者（ACS）75例，稳定性心绞痛组（SAP）46例；另设正常对照组（CONTROL）50例。采用酶联免疫吸附法（ELISA）测定各病例入院后即刻、术后即刻、术后1周血清LOX-1浓度。结果 入院即刻，ACS组、SAP组及对照组血清 LOX-1浓度分别为(216.38±40.67) 、(181.51±34.66) 、(154.43±27.41)μg/ L。ACS组与SAP组之间LOX-1浓度差异有统计学意义(P <0.05), SAP 组与对照组之间差异也有统计学意义(P<0.05)。PCI术后即刻与入院即刻相比，LOX-1浓度无显著差异。PCI术后1周LOX-1浓度较术前降低,但差异无统计学意义。结论 ACS患者外周血清LOX-1浓度明显升高，其水平与冠状动脉内粥样硬化斑块的稳定性密切相关, 提示其可作为动脉粥样硬化斑块不稳定的血清学指标。

关键词: 急性冠脉综合征, 凝集素样氧化低密度脂蛋白受体-1, 经皮冠状动脉介入治疗

Abstract: [Abstract] 　Objective　To investigate the correlation between serum level of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and acute coronary syndrome (ACS ). Method There are 121 patients with coronary heart diseases (CHD) confirmed by CAG including 75 ACS patients,46 SAP patients,and 50 healthy subjects as the control group. Every sample’s serum LOX-1 level is detected by ELISA method. Results　On admission, the concentration of LOX-1 in ACS, SAP and control group is (216.38±40.67) 、(181.51±34.66)、(154.43±27.41)μg/L respectively；There is remarkable statistical difference between ACS and SAP group,and so is it between SAP and control group.There is no statistical difference of the level of LOX-1 between immediately after PCI and that before PCI. 1 week after PCI，the level of LOX-1 is lower than that before PCI， but there is no statistical difference between them. Conclusions The serum concentration of LOX-1 is higher obviously in ACS patients,and it is related to the stability of coronary plaque ,which shows LOX-1 may serve as a potential marker of plaque instability and could be the important monitering markers for the severity of ACS.

Key words: acute coronary syndrome(ACS), lectin - like oxidized lowdensity lipoprotein receptor-1(LOX-1), percutaneous coronary intervention(PCI)