天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (3): 330-332.doi: 10.11958/j.issn.0253-9896.2015.03.029

• 综述 • 上一篇    下一篇

流感嗜血杆菌自身因子在生物膜形成过程中的作用

高雪 1， 尚小领 2， 张玉妥 1△   

  1. 1张家口， 河北北方学院病原生物与免疫学研究所 （邮编075000）； 2河北北方学院附属第一医院耳鼻咽喉头颈外科
  • 收稿日期:2014-05-04 修回日期:2014-09-21 出版日期:2015-03-15 发布日期:2015-03-15
  • 通讯作者: 张玉妥 E-mail:15369333609@163.com
  • 基金资助:
    河北省卫生厅医学科学研究重点课题 （20110537）

Role of haemophilus influenza factor in the process of biofilm formation

GAO Xue1, SHANG Xiaoling2, ZHANG Yutuo1△#br# #br#   

  1. 1 Institute of Pathogen Biology and Immunology of Hebei North University, Zhangjiakou 075000, China; 2 Department of Otolaryngology Head and Neck Surgery of the First Affiliated Hospital of Hebei North University
  • Received:2014-05-04 Revised:2014-09-21 Published:2015-03-15 Online:2015-03-15
  • Contact: ZHANG Yutuo E-mail:15369333609@163.com

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摘要： 流感嗜血杆菌（Haemophilus influenzae, Hi）是人体上呼吸道常见寄生菌， 当机体免疫力低下时， 可引起发病； 当 Hi 在感染部位形成生物膜（Biofilm， BF）后， 对抗生素的敏感性下降， 常引起疾病慢性化， 使临床治疗变得棘手。近年来， Hi BF 的致病性和 BF 形成相关自身因子已渐渐成为临床和基础研究学者关注的热点， 本文就近年来国内外的报道综述如下。

关键词: 嗜血菌, 流感； 生物膜； 药物耐受性； 综述

Abstract: The Haemophilus influenzae (Hi) is a common opportunistic pathogen from human respiratory tract. The lower immunity can cause the disease. After the biofilm (BF) is formatted by Hi at the site of infection, the antibiotic sensitivity is declined, which often causes the chronic disease, inducing the difficulty in clinical treatment. In recent years, the pathogenicity of Hi BF and BF form related factors have gradually become the focus of clinical and basic research. This paper reviewed recent studies as following.

Key words: haemophilus influenza, biofilms, drug tolerance, review