天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (1): 98-101.doi: 10.11958/58643

• 应用研究 • 上一篇    下一篇

头面部恶性肿瘤18 F-FDG 符合线路/CT 显像 T/N 比值分析

李楠， 毛夕保， 丁晨旻， 包文骏， 范晶， 薛宁娟   

  1. 常州市第四人民医院、 苏州大学附属常州肿瘤医院核医学科 （邮编213001）
  • 收稿日期:2015-03-20 修回日期:2015-07-29 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 李楠 E-mail:kukud002@sina.com
  • 作者简介:李楠 （1981）， 女， 主管技师， 学士， 主要从事核医学技术在临床中的应用研究

The target/no target ratio analysis of 18 F-FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging

LI Nan, MAO Xibao, DING Chenmin, BAO Wenjun, FAN Jing, XUE Ningjuan   

  1. Department of Nuclear Medicine, Changzhou Fourth People’ s Hospital, Changzhou Cancer Hospital of Soochow University, Changzhou 213001, China
  • Received:2015-03-20 Revised:2015-07-29 Published:2016-01-15 Online:2016-01-15
  • Contact: Nan LI E-mail:kukud002@sina.com

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摘要： 摘要： 目的 探讨头面部恶性肿瘤治疗后 18 F-脱氧葡萄糖 （FDG） 符合线路/CT 显像中 18 F-FDG 摄取程度的影响因素。方法 对 32 例经手术治疗、 放疗或放疗加化疗后头面部恶性肿瘤患者 18 F-FDG 符合线路/CT 显像图进行分析， 计算靶/非靶摄取 （T/N） 比值， 并按性别、 年龄、 空腹血糖浓度、 原发病灶直径、 肿瘤部位、 肿瘤病理类型、 肿瘤细胞分化程度、 治疗方式进行组间比较。结果 年龄>70 岁组 T/N 比值大于 41~50 岁和 51~60 岁组 （均 P < 0.05）； 病灶直径＜2 cm 组 T/N 比值低于直径 2~5 cm 及直径＞5 cm 组 （均 P＜0.05）； 原发肿瘤细胞低分化小于未分化组 （P < 0.05）。其余分析指标组间 T/N 比值差异均无统计学意义 （均 P > 0.05）。多重线性回归分析结果示， T/N 比值 （Y） 与患者年龄 （X2 ）、 原发病灶直径 （X4 ） 和肿瘤细胞分化程度 （X9 ） 相关：=-4.389 25+0.053 03 X2+1.617 86 X4+0.718 35 X9。结论 患者年龄＞70 岁、 原发灶直径≥2 cm、 肿瘤细胞未分化的头面部恶性肿瘤治疗后残余或复发可能性较大， 特别应重视这部分患者的随访诊疗。

关键词: 头颈部肿瘤, 肿瘤复发, 局部, 放射性核素体层摄影术, 单光子发射型计算机, 脱氧葡萄糖, 符合线路

Abstract: Abstract： Objective To investigate the influencing factors of 18 F- FDG uptaking in head and neck malignancy by SPECT/CT coincidence imaging. Methods 18 F-FDG SPECT/CT coincidence imaging was performed in 32 patients with head and neck malignancy after surgery, radiotherapy or radiotherapy + chemotherapy. The radio of target/no target (T/N) was calculated. The gender, age, fasting blood glucose level, size of tumor, location of tumor, pathological classification, de⁃ gree of cell differentiation and treatment modalities were analyzed between groups. Results The single-factor analysis of variance showed that the T/N value was significantly higher in >70 yeas old, group than that of 41-50 yeas old group and 51-60 yeas old group (P < 0.05). The T/N value was significantly lower in tumor size <2 cm group than that of 2-5 cm group and > 5 cm group (P＜0.05). And it was lower in poor differentiated tumor group than that of. undifferentiated tumor group (P < 0.05). There were no significant differences in T/N values between other indicator groups (P > 0.05). The multiple linear regression analysis showed that 18 F-FDG uptaking in head and neck malignancy (T/N=Y) was related to the age of patients (X2), the diameter of tumor (X4) and the degree of cell differentiation (X9): =-4.389 25+0.053 03 X2+1.617 86 X4+ 0.718 35 X9. Conclusion Tumor recurrence is more likely to occur in patients with age >70 years old, the diameter of tumor ≥2 cm, and the anaplastic head and neck malignancy.We should pay much attention to the diagnosis and follow-up for these pa⁃ tients.

Key words: head and neck neoplasms, neoplasm recurrence, local, radionuclide tomography, single photon emission omputed, deoxyglucose, coincidence