天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (7): 914-916.doi: 10.11958/20150145

• 药物临床观察 • 上一篇    下一篇

曲美他嗪治疗冠状动脉肌桥疗效观察

张建艳1,郭兆增1,2,曹月娟1,2   

  1. 天津市人民医院心脏二科（邮编 300121）
  • 收稿日期:2015-09-02 修回日期:2016-02-17 出版日期:2016-07-15 发布日期:2016-07-15
  • 通讯作者: 曹月娟 E-mail:zjyllyy@126.com
  • 作者简介:张建艳（1978）， 女， 硕士研究生， 主要从事心血管疾病方面研究

Treatment Effects of?Trimetazidine on coronary artery bridge

ZHANG Jianyan, GUO Zhaozeng, ZHANG Tao, MA Xuejiao, CAO Yuejuan   

  1. Department of Cardiology, Tianjin Union Medical Center, Tianjin 300121, China
  • Received:2015-09-02 Revised:2016-02-17 Published:2016-07-15 Online:2016-07-15
  • Contact: 曹月娟 E-mail:zjyllyy@126.com

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摘要： 目的 观察曲美他嗪治疗冠状动脉肌桥的效果。方法 选择2014年5月至2015年2月因不同程度胸闷、心悸、气短、心前区疼痛等心脏不适症状在我院心内科住院经冠脉造影检查发现的心肌桥患者76例，随机分为两组:对照组40例，给予β受体阻滞剂或（和）钙拮抗剂为基础的常规治疗;治疗组 36例，在β受体阻滞剂或（和）钙拮抗剂常规治疗基础上加用曲美他嗪，平均随访12周，观察比较两组患者每周胸痛发作次数、运动耐量、焦虑及抑郁评分、24小时缺血总负荷、6分钟最远步行距离等改善情况。结果 治疗组与对照组相比，每周胸痛发作次数、运动耐量、焦虑及抑郁评分、24小时缺血总负荷、6分钟最远步行距离改善，能有效缓解症状，提升患者生活质量。结论 常规治疗基础上加用曲美他嗪治疗安全有效，可进一步改善心肌能量代谢及运动耐量，提高临床疗效及患者生活质量。

关键词: 冠状动脉疾病, 心肌疾病, 曲美他嗪, 运动耐量, 冠状动脉肌桥

Abstract: Objective To observe the treatment effects of trimetazidine on myocardial bridge. Methods A total of 76 patients with clinical symptoms, such as different degree of chest tightness, palpitations, breath shortness, chest pain, were diagnosed as coronary myocardial bridge by coronary angiography and divided into 2 groups randomly. While control group (n=40) were given beta-blockers or (and) calcium antagonistas routine treatment, treatment group (n=36) were given routine treatment and trimetazidine, 20mg every time, tid. Chest pain times per week, exercise tolerance, anxiety and depression scores, total ischemic burden in 24h and walking distance in 6min, were observed in 2 groups during follow-up of 12 weeks. Results Compared with control group, those of treatment group were all improved. Conclusion Treatment based on conventional treatment combined with trimetazidine is safe and effective, can further improve myocardial energy metabolism and exercise tolerance, improves the clinical effect and the life quality of patients

Key words: coronary artery disease, cardiomyopathies, trimetazidine, exercise tolerance, coronary myocardial bridge