天津医药 ›› 2016, Vol. 44 ›› Issue (2): 234-236.doi: 10.11958/20150136

• 应用研究 • 上一篇    下一篇

经导管去肾交感神经术治疗高血压性心脏病合并心衰 患者的效果分析

夏大胜, 卢成志, 王丽   

  1. 天津市第一中心医院心内科 (邮编300192)
  • 收稿日期:2015-08-31 修回日期:2015-10-29 出版日期:2016-02-15 发布日期:2016-02-15
  • 基金资助:
    天津市科技支撑项目 (14JCYBJC26100); 天津市卫生局科技基金面上项目 (2014KY11)

Renal sympathetic denervation for the treatment of hypertensive heart disease with systolic heart failure

XIA Dasheng, LU Chengzhi, WANG Li   

  1. Department of Cardiology of Tianjin First Center Hospital, Tianjin 300192,China
  • Received:2015-08-31 Revised:2015-10-29 Published:2016-02-15 Online:2016-02-15

摘要: 目的 评估经导管去肾交感神经术(RDN)治疗高血压性心脏病合并收缩性心衰患者的有效性。方法对 2 例高血压性心脏病合并心衰患者进行 RDN, 于术前及术后 1 年行心脏彩超、 6 分钟步行试验和肾功能、 糖化血红蛋白、 N-末端脑钠肽前体(NT-ProBNP)等检查, 评估治疗效果。结果 2 例患者行 RDN 后, 肾动脉造影显示肾动脉无狭窄及夹层等并发症。1 年后随访, 2 例患者的 6 分钟步行试验结果、 左室射血分数、 NT-proBNP 等心功能指标明显改善, 左心室明显减小。结论 RDN 对高血压性心脏病合并收缩性心衰患者的治疗有效、 可行。

关键词: 经导管去肾交感神经术, 收缩性心衰, 高血压

Abstract: Objective To evaluate the effectiveness of renal sympathetic denervation (RDN) for hypertensive heart dis⁃ ease combined with systolic heart failure. Methods Two patients (mean age 35 years) with hypertensive heart disease combined with systolic heart failure on maximal tolerated heart failure therapy underwent bilateral renal denervation. Echocardiography, the six minute walk distance, renal function, glycosylated hemoglobin and NT-proBNP were assessed at baseline and 1 year after renal denervation. Results Renal artery angiography showed that no stenosis and dissection. After 1 year follow up, the left ventricular ejection fraction (LVEF), six minute walk distance and NT- proBNP were significantly improved, and the size of left ventricular decreased. Conclusion RDN is effective and feasible for the treatment in patients with hypertensive heart disease and systolic heart failure.

Key words: renal sympathetic denervation, systolic heart failure, hypertension