天津医药 ›› 2017, Vol. 45 ›› Issue (7): 781-784.doi: 10.11958/20170579

• 综述 • 上一篇    

IL-17 与糖尿病及糖尿病肾病关系的研究进展

吕元军,李长平   

  1. 1 天津市天津医院普通内科 (邮编 300211); 2 天津医科大学公共卫生学院
  • 收稿日期:2017-05-18 修回日期:2017-06-13 出版日期:2017-07-15 发布日期:2017-08-08
  • 通讯作者: 李长平 E-mail:lyj22337@163.com
  • 基金资助:
    国家自然科学基金青年基金项目 (81200611); 天津市卫生局科技基金项目 (2011KY22, 2010KZ55)

Research progress of the relationship between IL-17, diabetes and diabetic nephropathy

LYU Yuan-jun,LI Chang-ping   

  1. Division of General Internal Medicine, Tianjin Hospital, Tianjin 300211, China; 2 School of Public Health, Tianjin Medical University
  • Received:2017-05-18 Revised:2017-06-13 Published:2017-07-15 Online:2017-08-08
  • Contact: LI Chang-ping E-mail:lyj22337@163.com

摘要: 近年来糖尿病患病率迅速增高, 已经成为严重的世界性公共卫生问题。糖尿病肾病是导致终末期肾功能衰竭的主要原因, 也是糖尿病最常见的慢性并发症之一。然而, 糖尿病以及糖尿病肾病的发病机制至今仍没有完全阐明。白细胞介素(IL) -17 在自身免疫性疾病及炎性疾病中发挥了重要的作用。本文就 IL-17 在糖尿病和糖尿病肾病发病过程中的作用进行综述。

关键词: 糖尿病, 1 型, 糖尿病, 2 型, 糖尿病肾病, 白细胞介素 17, 辅助性 T 细胞 17

Abstract: In recent years, the prevalence of diabetes has increased rapidly, and which has become a serious public health problem worldwide. Diabetic nephropathy is a major cause of end-stage renal failure, which is also one of the most common chronic complication of diabetes. However, the pathogenesis of diabetes and diabetic nephropathy has not been fully elucidated up to now. IL-17 plays a key role in autoimmune disease and inflammatory disease. This article reviews the role of IL-17 in the pathogenesis of diabetes and diabetic nephropathy.

Key words: diabetes mellitus, type 1, diabetes mellitus, type 2, diabetic nephropathy, interleukin-17, Th17

中图分类号: