天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (1): 70-73.doi: 10.11958/20170925

• 临床研究 • 上一篇    下一篇

颞叶癫痫患者的睡眠特征研究

毛汕 1，潘立平 1，任艳苹 1，曹娟 1，吴丹 2，宋毅军 1△   

  1. 1 天津医科大学总医院神经内科，天津市神经病学研究所（邮编 300052）；2 天津医科大学宝坻临床学院神经内科
  • 收稿日期:2017-08-25 修回日期:2017-11-07 出版日期:2018-01-15 发布日期:2018-01-16
  • 通讯作者: 宋毅军 E-mail:songyijun2000@126.com
  • 作者简介:毛汕（1992），女，硕士在读，主要从事癫痫的基础及临床研究
  • 基金资助:
    天津市应用基础与前沿技术研究计划

Study of sleep features in patients with temporal lobe epilepsy

MAO Shan1, PAN Li-ping1, REN Yan-ping1, CAO Juan1, WU Dan2, SONG Yi-jun1△   

  1. 1 Department of Neurology, Tianjin Medical University General Hospital; Tianjin Neurological Institute, Tianjin 300052,China; 2 Baodi Clinical College of Tianjin Medical University
  • Received:2017-08-25 Revised:2017-11-07 Published:2018-01-15 Online:2018-01-16
  • Contact: yijun song E-mail:songyijun2000@126.com

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摘要： 目的 通过多导睡眠监测（PSG）研究颞叶癫痫（TLE）患者发作间期的睡眠特征。方法 选取 25 例 TLE 患者为 TLE 组，健康志愿者 18 例为对照组，对 2 组受试者分别进行 PSG，监测指标包括总卧床时间（TIB）、总睡眠时 间（TST）、睡眠效率（SE）、睡眠潜伏期（SL）、快速动眼睡眠期潜伏期（REML）、入睡后觉醒时间（WASO）、非快速动眼 睡眠（NREM）1、2、3 期以及快速动眼睡眠期（REM）时间占总睡眠期时间的百分比（以 N1%、N2%、N3%、REM%表 示）、呼吸暂停低通气指数（AHI）、低通气指数、平均血氧饱和度（SpO2）及最低 SpO2、觉醒指数、每小时周期性肢体运 动指数（PLMs/h）、每小时 REM 期 PLMs、总睡眠期转换次数（SSS）、每小时睡眠期转换次数（SSS/H）、NREM1、2、3 期 以及 REM、清醒期转换次数（以 N1、N2、N3、REM、W 表示）、N1、N2、N3、REM、清醒期转换次数占总睡眠期转换次数 百分比（以 N1/SSS、N2/SSS、N3/SSS、REM/SSS、W/SSS 表示）等睡眠指标。结果 与对照组相比，TLE 组 WASO 延长， 平均 SpO2降低，PLMs 增多，REM 期 PLMs 增多，SSS、SSS/H 及 N2 增多（P＜0.05）。结论 TLE 患者存在睡眠障碍， 主要表现为睡眠结构明显紊乱，睡眠相关呼吸、运动事件增多。

关键词: 癫痫, 颞叶, 睡眠障碍, 多导睡眠监测, 睡眠结构, 睡眠相关事件

Abstract: Objective To study sleep characteristics in patients with temporal lobe epilepsy (TLE) through polysomnography (PSG). Methods Twenty-five TLE patients (TLE group) and eighteen healthy volunteer subjects (control group) were recruited to our study. Patients of two groups were evaluated by whole-night PSG, including total time in bed (TIB), total sleep time (TST), sleep efficiency (SE), sleep latency (SL), rapid eye movement latency (REML), wake after sleep onset (WASO), the percentages of non-REM (NREM) 1, 2 and 3 stages and the percentages of rapid eye movement (REM) occupied TST (N1%, N2%, N3% and REM%), the apnea- hypopnea index (AHI), hypopnea index, mean oxygen saturation (SpO2) and nadir SpO2, periodic leg movements (PLMs) index and PLMs index of REM sleep, sleep stage shifts (SSS) and sleep stage shifts per hour (SSS/h), NREM1, NREM2, NREM3 and REM sleep stage and wake shifts (abbreviated as N1, N2, N3, REM and W) and their proportions of SSS (abbreviated as N1/SSS, N2/SSS, N3/SSS, REM/SSS and W/SSS). Results Compared with control group, WASO, PLMs, PLMs index of REM sleep, SSS, SSS/H and N2 were significantly increased in TLE group. Moreover, compared with control group, SpO2 was decreased in TLE group (P＜0.05). Conclusion Our results suggest that TLE patients have sleep disorder manifested as disorder of sleep structure, increased incidents of respiratory and motion events.

Key words: epilepsy, temporal lobe, sleep disorder, polysomnography, sleep structure, respiratory events