天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (8): 899-904.doi: 10.11958/20180156

• 综述 • 上一篇    

胰腺癌侵袭转移作用机制的研究进展

陈小艳1 ， 贾建新2   

  1. 1包头医学院病理学教研室， 包头医学院第一附属医院病理科 （邮编014040）； 2包头医学院解剖学教研室
  • 收稿日期:2018-01-26 修回日期:2018-04-10 出版日期:2018-08-15 发布日期:2018-08-23
  • 通讯作者: 陈小艳 E-mail:79109267@qq.com
  • 基金资助:
    包头市医药卫生科技计划项目

Study on mechanism of invasion and metastasis of pancreatic cancer

CHEN Xiao-yan1 , JIA Jian-xin2   

  1. 1 Department of Pathology, Baotou Medical College, The First Affiliated Hospital of Baotou Medical College, Baotou 014040, China; 2 Department of Anatomy of Baotou Medical College
  • Received:2018-01-26 Revised:2018-04-10 Published:2018-08-15 Online:2018-08-23

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摘要： 胰腺癌是一种病死率极高的恶性肿瘤， 其起病隐匿、 发展迅速， 容易早期发生淋巴及肝转移。目前胰腺癌侵袭转移机制的研究逐渐深入， 本文主要从小干扰RNA、 非编码RNA、 缺氧方面以及表皮生长因子及其受体、 基质源性细胞因子、 叉头框M1 （FOXM1）、 双肾上腺皮质激素样激酶1 （DCLK1） 等蛋白分子在胰腺癌侵袭转移中的作用进行简要概述， 它们通过作用于靶基因或相关信号通路促进细胞增殖、 抑制细胞凋亡、 促进血管生成和肿瘤细胞上皮间质转化， 或者改变肿瘤细胞代谢， 从而与胰腺癌的恶性进展、 侵袭和转移等行为密切相关。

关键词: 胰腺肿瘤, 肿瘤侵润, 肿瘤转移, 综述

Abstract: Pancreatic cancer is a kind of malignant tumor with extremely high mortality rate, and its onset is insidious and it develops rapidly. It is very easy to have lymphatic node and liver metastasis in early stage. At present, the research on the mechanism of invasion and metastasis of pancreatic cancer is getting deeper. This review summarized mainly by miRNAs, non encoded RNAs, hypoxia and epidermal growth factor (EGF) and its receptors, CXCL12 and FOXM1, DCLK1 protein molecules, which played the role in invasion and metastasis of pancreatic cancer. They act on target genes or related signaling pathways to promote cell proliferation, inhibit cell apoptosis and promote angiogenesis and EMT in tumor cells. They also alter tumor cell metabolism, which is closely related to malignant progress, invasion and metastasis in the pancreatic cancer.

Key words: pancreatic neoplasms, neoplasm invasiveness, neoplasm metastasis, review