天津医药

天津医药 ›› 2019, Vol. 47 ›› Issue (10): 1062-1066.doi: 10.11958/20191021

• 临床研究 • 上一篇    下一篇

T-SPOT.TB在肺结核早期抗痨治疗有效过程中的 变化趋势研究

李晓非△，刘红伟，罗风，邱万   

  1. 昆明市第三人民医院检验科（邮编650041）
  • 收稿日期:2019-04-02 修回日期:2019-07-16 出版日期:2019-10-15 发布日期:2019-11-11
  • 通讯作者: 罗风 E-mail:18790698739@163.com
  • 基金资助:
     

Trend of T-SPOT.TB in the effective process of early antituberculosis treatment of tuberculosis

LI Xiao-fei△, LIU Hong-wei, LUO Feng, QIU Wan   

  1. Department of Clinical Laboratory, the third People’s Hospotal of Kunming, Kunming 650041, China
  • Received:2019-04-02 Revised:2019-07-16 Published:2019-10-15 Online:2019-11-11
  • Contact: Luo-Feng ZHANG E-mail:18790698739@163.com
  • Supported by:
     

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摘要： 摘要：目的 研究结核感染T细胞试验（T-SPOT.TB）在肺结核早期抗痨治疗有效过程中的变化趋势。方法 选 择2016年6月—2019年2月于我院结核科进行正规抗痨治疗的50例确诊初治活动性肺结核患者为研究对象，分析 其抗痨治疗前、治疗后（30 d、1个月、3个月）这4个时间点T-SPOT.TB结果动态变化趋势，及治疗前、后机体对结核分 枝杆菌特异性抗原［早期分泌靶向抗原6（ESAT-6）、培养滤液蛋白10（CFP-10）］刺激应答水平变化。结果 在为期 3 个月有效抗痨治疗期间，随着治疗时间的延长，T-SPOT.TB 结果大体呈逐步下降趋势，差异有统计学意义（P＜ 0.05）。治疗3个月后机体对ESAT-6、CFP-10刺激免疫应答变化一致。结论 T-SPOT.TB可能成为监测肺结核疗效 的良好指标；抗痨治疗有效后（第3个月时）机体对ESAT-6、CFP-10刺激应答水平变化一致。

关键词: 肺结核, 结核感染T细胞检测, 结果变化, 治疗监测

Abstract: Abstract：Objective To study the change trend of T-cell spot of Tuberculosis (T-SPOT.TB) in the effective process of early anti-tuberculosis treatment of tuberculosis. Methods Fifty newly diagnosed patients with active pulmonary tuberculosis who received regular anti-tuberculosis treatment in tuberculosis department of our hospital from June 2016 to February 2019 were selected as subjects of the study. The dynamic change trend of T-SPOT.TB results and the changes of body's response to tuberculosis specific antigen [early secreting antigen target-6 (ESAT-6), culture filtrate protein-10 (CFP- 10)] stimulation before and after anti-tuberculosis treatment (30 days, 1 month and 3 months) were analyzed. Results During the period of effective anti-tuberculosis treatment of three months, the results of T-SPOT.TB decreased gradually with the prolongation of treatment time, and the difference was statistically significant (P＜0.05). The changes of immune response to ESAT-6 and CFP-10 were consistent after treatment for three months. Conclusion T-SPOT.TB may be a good indicator for monitoring the efficacy of tuberculosis. The changes of body response to ESAT-6 and CFP-10 are consistent after anti-tuberculosis treatment (at the 3rd month).

Key words: pulmonary tuberculosis, T-SPOT.TB, result change, treatment monitoring

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