天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (5): 442-448.doi: 10.11958/20192821

• 循证医学 • 上一篇    下一篇

低表达抑癌环状RNA在胃癌诊断及预后中作用的Meta分析 #br#

刘云 1，张曼玲 1，彭洪娇 1，时昭红 2△
  

  1. 1湖北中医药大学（邮编430000）；2湖北中医药大学附属武汉市第一医院

  • 收稿日期:2019-09-12 修回日期:2020-01-13 出版日期:2020-05-15 发布日期:2020-06-24
  • 通讯作者: 时昭红 E-mail:ycfyx2000@126.com
  • 基金资助:
    国家重点研发计划（2017YFC1700601）

Prognostic and diagnostic significance of circRNA low-expression in gastric cancer patients: A meta-analysis #br#

LIU Yun 1, ZHANG Man-ling1, PENG Hong-jiao1, SHI Zhao-hong2△ #br#   

  1. 1 Hubei University of Traditional Chinese Medicine, Wuhan 430000, China; 2 Wuhan NO.1 Hospital Affiliated to
    Hubei University of Traditional Chinese Medicine
  • Received:2019-09-12 Revised:2020-01-13 Published:2020-05-15 Online:2020-06-24

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摘要： 目的 通过Meta分析探讨低表达环状RNA（circRNA）对胃癌诊断及预后判断中的价值。方法 检索国外
主要医学数据库，包括 PubMed，Embase和 Web of science，搜索有关 circRNA与胃癌预后及诊断的相关研究，检索时
限均为建库至 2019年 6月。由 3名研究者独立筛选文献，提取相关数据并评价纳入研究的偏倚风险，采用 Stata 14.0
进行 Meta分析。结果 共有 20篇文献纳入研究，9篇文献进行预后 Meta分析，16篇文献进行诊断 Meta分析。结果
发现低表达抑癌circRNA与更差的临床病理特征相关，预后Meta分析结果显示高表达抑癌circRNA与较好的总生存
期（OS）相关（HR=0.37，95%CI：0.29~0.48），诊断 Meta分析结果显示汇总后的敏感度为 0.73（95%CI：0.66~0.79），特异
度为 0.77（95% CI：0.68~0.84），汇总受试者工作特征曲线（SROC）AUC为 0.81（95% CI：0.77~0.84）。结论 低表达抑
癌circRNA对胃癌患者预后判断及诊断均有一定价值，但仍需要更多高质量的临床研究进一步证实。

关键词: 胃肿瘤, 癌, 诊断, 预后, 环状RNA, Meta分析

Abstract: Objective To systematically evaluate the role of the low expression level of circRNA in the diagnosis and
prognosis of gastric cancer. Methods The English databases including PubMed, EMbase and Web of Science were
systematically searched with the search time from the establishment of the database to June 2019. All eligible studies
associated with circRNA and prognosis or diagnosis in gastric cancer were included. Three researchers independently
screened the included studies, extracted data and evaluated the quality. The Stata 14.0 software was used for Meta-analysis.
Results A total of 20 relevant studies were eligible, including 9 on prognosis and 16 on diagnosis. As for
clinicopathological parameters, the low expression of antineoplastic circRNAs showed a significant association with poor
clinicopathological features. For the prognostic values, high-regulated antineoplastic circRNAs showed the favorable impact
on overall survival (HR=0.37, 95% CI: 0.29-0.48). The results revealed a sensitivity of 0.73 (95%CI: 0.66-0.79), a
specificity of 0.77 (95% CI：0.68-0.84), and an AUC of 0.81(95% CI: 0.77-0.84) for gastric cancer diagnosis with circRNAs.
Conclusion The low expression of circRNA has certain value in the prognosis and diagnosis of gastric cancer, but it still
needs more high-quality clinical research to further confirm.

Key words: stomach neoplasms, diagnosis, prognosis, circRNA, Meta-analysis