天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (7): 647-650.doi: 10.11958/20200754

• 临床研究 • 上一篇    下一篇

原发扁桃体非霍奇金淋巴瘤21例临床分析

曹丽红1 ，赵雪2 ，李尧3 ，王建玲3△   

  1. 1 天津医科大学总医院空港医院医疗美容科（邮编 300308）；2 天津医科大学总医院病理科，3 耳鼻喉科
  • 收稿日期:2020-03-31 修回日期:2020-04-23 出版日期:2020-07-15 发布日期:2020-07-16
  • 作者简介:曹丽红（1973），女，硕士，主治医师，主要从事头颈肿瘤和五官整形方面研究

Clinical analysis of 21 primary non-Hodgkin's lymphoma of the tonsil

CAO Li-hong1 , ZHAO Xue2 , LI Yao3 , WANG Jian-ling3△   

  1. 1 Department of Medical Cosmetology, Tianjin Medical University General Hospital Airport Hospital, Tianjin 300308, China; 2 Department of Pathology, 3 Department of Otolaryngology, Tianjin Medical University General Hospital
  • Received:2020-03-31 Revised:2020-04-23 Published:2020-07-15 Online:2020-07-16

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摘要： 目的 探讨原发扁桃体非霍奇金淋巴瘤（NHL）的临床病理特征、诊断治疗及预后。方法 回顾性分析天 津医科大学总医院2007年1月—2014年1月收治的经病理确诊的21例原发扁桃体NHL的临床资料，总结其临床病 理特点、分期及预后。结果 21例原发扁桃体NHL占同期行扁桃体手术病理患者的2.6%（21/807）。其中男13例， 女8例，平均发病年龄（50.8±12.9）岁。单侧发病19例（90.5%）。病理学诊断源于B细胞20例（95.2%），其中弥漫大B 细胞型13例（61.9%），滤泡性4例（19.0%），套细胞型3例（14.3%）；源于T细胞1例（4.8%）。按照Ann-Arbor标准分期 Ⅰ~Ⅱ期18例，5年生存率为71.4%；Ⅲ~Ⅳ期3例，5年生存率为0。结论 原发扁桃体NHL较为罕见，早期患者预后 较好，重视本病的早期诊断、早期治疗是提高5年生存率的关键。

关键词: 淋巴瘤, 非霍奇金；扁桃体肿瘤；腭扁桃体；病理；预后

Abstract: Objective To investigate the clinical and pathological features, treatment and prognosis in primary nonHodgkin's lymphoma (NHL) of the tonsil. Methods Data of 21 patients with tonsil NHL treated in Tianjin Medical University General Hospital from Jan 2007 to Jan 2014 were retrospectively analyzed. Results A total of 21 cases of original tonsil NHL accounted for 2.6% (21/807) of pathological diagnosis of tonsil surgery during the same period. There were 13 males and 8 females, the mean age was（50.8±12.9）years old. The unilateral disease were 19 cases (90.5%). The pathological classification: 20 cases (95.2%) were B-cell subtype including diffuse large B-cell lymphoma (DLBCL) 13 cases (61.9%), follicular lymphoma (FL) 4 cases (19.0%) and mucosa associated lynmphoid tissue (MALT) 3 cases (14.3%); 1 case was T-cell subtype (4.8%). According to the Ann-Arbor standard, 18 cases (85.7%) were stage Ⅰ-Ⅱ, 3 cases (14.3%) were stage Ⅲ - Ⅳ . The 5 year survival of stage Ⅰ - Ⅱ patients was 71.4%, of stage Ⅲ - Ⅳ patients was 0%. Conclusion Primary tonsil NHL is rare and the prognosis at early stages is good. The key to improve the 5-year survival rate is to pay attention to the early diagnosis and treatment of the disease.

Key words: lymphoma, non-Hodgkin, tonsillar neoplasms, palatine tonsil, pathology, prognosis