天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (10): 920-924.doi: 10.11958/20201541

• 新冠专题 • 上一篇    下一篇

新型冠状病毒肺炎潜在的发病机制及间充质干细胞治疗作用的研究进展

赵亚萍1，马辉2，曹洁2△   

  1. 1天津医科大学总医院空港医院呼吸科（邮编300300）；2天津医科大学总医院呼吸科
  • 收稿日期:2020-06-01 修回日期:2020-07-14 出版日期:2020-10-15 发布日期:2020-10-30
  • 通讯作者: 赵亚萍 E-mail:1521594190@qq.com
  • 基金资助:
    重叠综合征模式低氧致血管内皮损伤中性粒细胞与内皮细胞交互作用机制研究;睡眠呼吸暂停模式间歇低氧诱导癌相关成纤维细胞的激活和促进肿瘤转移机制的研究

The potential mechanism of coronavirus disease 2019 and the treatment effect of mesenchymal stem cells

ZHAO Ya-ping1, MA Hui2, CAO Jie2△   

  1. 1 Department of Respiratory Medicine, Tianjin Medical University General Hospital Airport Hospital, Tianjin 300300, China; 2 Department of Respiratory Medicine, Tianjin Medical University General Hospital
  • Received:2020-06-01 Revised:2020-07-14 Published:2020-10-15 Online:2020-10-30
  • Contact: Ya-Ping ZHAO E-mail:1521594190@qq.com
  • Supported by:
    国家自然科学基金资助项目（81670084、81970084）

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摘要：

摘要：新型冠状病毒肺炎（COVID-19）传染性强，重型患者病死率高，其发病机制尚不明确，缺乏特异性治疗方法。细胞因子风暴、免疫应答失衡可能是新型冠状病毒感染导致急性呼吸窘迫综合征（ARDS）及多脏器功能衰竭（MOF）甚至死亡的病生理基础。间充质干细胞（MSC）凭借其免疫调节、组织修复及抗纤维化等特性在COVID-19重症患者的救治中初显疗效，具有良好的临床应用前景。本文就COVID-19潜在的致病机制、MSC对COVID-19治疗的可能机制及在治疗中的应用进行综述，以期为临床治疗提供参考。

关键词: 肺炎, 病毒性；间充质基质细胞；肺纤维化；新型冠状病毒肺炎；间充质干细胞；细胞因子风暴；免疫调节；组织修复

Abstract:

Abstract: The coronavirus disease 2019 (COVID-19) is highly infectious, and the mortality of severe patients with the novel coronavirus pneumonia is high. Its pathogenesis is still unclear, and there is a lack of specific treatment method. The cytokine storm and imbalance of immune response may be the pathophysiological basis of acute respiratory distress syndrome (ARDS), multiple organ failure (MOF) and even death for the novel coronavirus pneumonia. Mesenchymal stem cells (MSC) has shown initial efficacy and clinical prospect in the treatment of severe patients by the immune regulation, tissue repair and anti-fibrosis properties. This article reviews the potential pathogenic mechanism of the COVID-19, the possible mechanism and application of MSC in the treatment of the COVID-19, which will provide reference for clinical treatment.

Key words: pneumonia, viral, mesenchymal stromal cells, pulmonary fibrosis, coronavirus disease 2019, mesenchymal stem cells, cytokine storm, immune regulation, tissue repair