天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (6): 662-667.doi: 10.11958/20203229

• 综述 • 上一篇    下一篇

lncRNA调控间充质干细胞向成骨细胞分化的研究进展 #br#

张瑞欣，董语迪 ，肖建辉
  

  1. 1遵义医科大学（邮编563000）；2遵义医科大学附属医院，遵义市医药生物技术重点实验室
  • 收稿日期:2020-11-19 修回日期:2021-02-08 出版日期:2021-06-15 发布日期:2021-06-15
  • 通讯作者: 张瑞欣 E-mail:zrxzrx0304@163.com
  • 基金资助:
    国家自然科学基金资助项目

Research progress of lncRNA regulating the differentiation of mesenchymal stem cells into osteoblasts #br#

ZHANG Rui-xin, DONG Yu-di, XIAO Jian-hui #br#   

  1. 1 Zunyi Medical University, Zunyi 563000, China; 2 Zunyi Medical University Affiliated Hospital, Zunyi Key Laboratory of
    Medicine and Biotechnology
  • Received:2020-11-19 Revised:2021-02-08 Published:2021-06-15 Online:2021-06-15
  • Contact: Rui-Xin ZHANG E-mail:zrxzrx0304@163.com

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摘要： 间充质干细胞（MSCs）是一种多能性基质细胞，已被证实具有向骨、软骨、脂肪、肌肉、神经、心肌和内皮等多种组织细胞分化的能力，且其在骨再生修复中发挥重要作用。长链非编码RNA（lncRNA）通过多种途径影响MSCs向成骨细胞分化的过程，同时在骨代谢平衡的过程中有着重要的调控作用。本文综述了lncRNA调控MSCs成骨分化的最新研究进展，为进一步研究lncRNA调节MSCs成骨分化及骨形成的机制提供新思路。

关键词: 间充质基质细胞, RNA, 长链非编码, 细胞分化, 骨再生

Abstract: Mesenchymal stem cells (MSCs) are pluripotent stromal cells, which have been proved to have abilities to differentiate into osteoblasts and adipocytes, and play an important role in bone regeneration and repair. Recent studies showed that long non-coding RNA (lncRNA) was differentially expressed in the process of osteogenic differentiation of MSCs, and affected the process of osteogenic differentiation of MSCs in many ways. It also played an important role in regulating the balance of bone metabolism. This paper reviewed the latest research progress of lncRNA in the regulation of osteogenic differentiation of MSCs and provided a new idea for further research on the mechanisms of lncRNA regulating the osteogenic differentiation and bone formation of MSCs.

Key words: mesenchymal stromal cells, RNA, long noncoding, cell differentiation, bone regeneration