天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (5): 556-560.doi: 10.11958/20203317

• 综述 • 上一篇    

小窝相关蛋白在乳腺癌中作用的研究进展

汪百川1，余岳2，李颖曦3，葛洁2，田垚4△   

  1. 1安徽省胸科医院，安徽医科大学临床学院（邮编230022）；2天津医科大学肿瘤医院，国家肿瘤临床医学研究中心；天津市“肿瘤防治”重点实验室；乳腺癌防治教育部重点实验室；3天津医科大学基础医学院病原生物学系；4天津医科大学总医院普通外科 
  • 收稿日期:2020-11-30 修回日期:2021-01-29 出版日期:2021-05-15 发布日期:2021-05-25
  • 通讯作者: 汪百川 E-mail:universedoctor@163.com
  • 基金资助:
    ALAD通过调控NF-κB信号通路抑制乳腺癌发展的机制研究

Research progress of caveolae-related proteins in human breast cancer

WANG Bai-chuan1, YU Yue2, LI Ying-xi3, GE Jie2, TIAN Yao4△   

  1. 1 Anhui Chest Hospital, Anhui Medical University Clinical College of Chest, Hefei 230022, China; 2 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University; 3 Department of Pathogen Biology, School of Basic Medical Sciences, Tianjin Medical University; 4 Department of General Surgery, Tianjin Medical University General Hospital
  • Received:2020-11-30 Revised:2021-01-29 Published:2021-05-15 Online:2021-05-25

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摘要： 摘要：小窝及其相关蛋白与乳腺癌的发生发展密切相关。小窝外壳蛋白包括Cav-1、Cav-2及Cav-3，其中Cav-1最受关注，其作为抑癌及促癌因子影响乳腺癌细胞的增殖、凋亡、迁移、侵袭以及转移。Cav-2也具有抑癌及促癌双重作用，其既可与Cav-1结合共表达，也可独自发挥调控作用。Cav-3在乳腺癌中研究较少，其表达缺失可形成抗肿瘤微环境。小窝接头蛋白（Cavins）包括Cavin-1、Cavin-2、Cavin-3及Cavin-4。Cavin-1可抑制Cav-1诱导的细胞膜小管形成，其在乳腺癌中发挥的具体作用仍存争议。Cavin-2作为乳腺癌抑制因子，可通过阻断转化生长因子（TGF）-β信号通路，抑制乳腺癌进展。Cavin-3在乳腺癌中发挥抑癌功能，而其具体作用机制尚不清楚。Cavin-4与乳腺癌间关系尚不明确。

关键词: 乳腺肿瘤, 膜蛋白质类, 细胞质膜微囊蛋白, 肿瘤转移, Cavins

Abstract: Abstract: Caveolae and its related proteins are closely related to the occurrence and development of breast cancer. Caveolins include Cav-1, Cav-2 and Cav-3, among which Cav-1 is the most concerned. According to different molecular types and stages of breast cancer, Cav-1 play a dual role as tumor suppressor and tumor promoter and affect cell proliferation, apoptosis, migration, invasion and metastasis of tumor. Cav-2 can also inhibit and promote cancer. Cav-2 can not only cooperate with Cav-1, but also play a regulatory role independently. At present, Cav-3 is less studied in breast cancer. Alblation of Cav-3 can form an anti-tumor microenvironment. Cavins include Cavin-1, Cavin-2, Cavin-3 and Cavin-4. Cavin-1 can inhibit membrane tubule formation induced by Cav-1, and its specific role in breast cancer remains controversial. As a breast cancer suppressor, Cavin-2 can inhibit the progression of breast cancer by blocking TGF - β signaling pathway. Cavin-3 plays an anti-tumor role in breast cancer, but its specific mechanism is still unclear. The relationship between Cavin-4 and breast cancer is still not clear.

Key words: breast neoplasms, membrane proteins, Caveolins, neoplasm metastasis, Cavins