天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (9): 987-991.doi: 10.11958/20210276

• 临床研究 • 上一篇    下一篇

血清IL-34及CTRP13水平与不稳定型心绞痛合并糖尿病的关系探讨#br#

刘慧卿1，金凤表2，吕苗苗1，高宇2，侯瑞田1△   

  1. 1. 承德医学院附属医院
    2. 承德医学院附属医院心内科
  • 收稿日期:2021-01-29 修回日期:2021-05-11 出版日期:2021-09-15 发布日期:2021-09-18
  • 通讯作者: 侯瑞田 E-mail:hrt65@sohu.com
  • 作者简介:统计结果忘了，若需要再让作者提供

Correlation between serum levels of IL-34 and CTRP13 and unstable angina with type 2 diabetes mellitus#br#

LIU Hui-qing1, JIN Feng-biao2, LYU Miao-miao1, GAO Yu2, HOU Rui-tian1△   

  • Received:2021-01-29 Revised:2021-05-11 Published:2021-09-15 Online:2021-09-18
  • Contact: hou ruitian E-mail:hrt65@sohu.com

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摘要： 摘要：目的　探讨血清白细胞介素（IL）-34、补体C1q/肿瘤坏死因子相关蛋白13（CTRP13）与不稳定型心绞痛（UA）合并2型糖尿病（T2DM）的关系。方法　选取150例行冠状动脉造影检查的患者，结合临床表现和实验室检查分为UA合并糖尿病（UA+T2DM）组50例、单纯UA（UA）组50例、单纯T2DM（T2DM）组50例，选取同期健康体检者50例为对照组。采用酶联免疫吸附试验测定血清IL-34和CTRP13水平。分析各组临床指标差异，相关性分析探究UA+T2DM组IL-34、CTRP13与腰围（WC）、体质量指数（BMI）、空腹血糖（FPG）、超敏C反应蛋白（hs-CRP）及Gensini积分的关系，受试者工作特征（ROC）曲线分析IL-34、CTRP13及两者联合对UA合并T2DM的诊断价值。结果　血清IL-34水平在对照组、T2DM组、UA组、UA+T2DM组依次升高，血清CTRP13水平在对照组、UA组、T2DM组、UA+T2DM组依次降低，UA+T2DM组Gensini积分显著高于UA组（均P＜0.05）。相关性分析显示，在UA+T2DM组，IL-34与WC、FPG、hs-CRP及Gensini积分呈正相关，与CTRP13呈负相关；CTRP13与hs-CRP、FPG及Gensini积分呈负相关（均P＜0.05）。ROC曲线结果显示，血清IL-34、CTRP13及两者联合诊断UA合并T2DM的曲线下面积分别为0.784（0.716~0.852）、0.820（0.759~0.882）和0.847（0.787~0.906）。结论　UA合并T2DM患者血清IL-34水平较高、CTRP13水平较低，IL-34和CTRP13对UA合并T2DM及其冠状动脉病变严重程度有一定的诊断及预测价值。

关键词: 心绞痛, 不稳定型；糖尿病, 2型；炎症；白细胞介素34；补体C1q/肿瘤坏死因子相关蛋白13；糖脂代谢

Abstract: Abstract: Objective　To investigate the correlation between IL-34, CTRP13 and unstable angina (UA) with type 2 diabetes mellitus (T2DM). Methods　A total of 150 patients admitted to the Affiliated Hospital of Chengde Medical University were collected and divided into 3 groups according to the clinical data and coronary angiography results: UA+T2DM group (n=50), UA group (n=50) and T2DM group (n=50)，and healthy people who had physical examination at the same period were selected as the control group (n=50). The serum levels of IL-34 and CTRP13 were detected by ELISA. The differences of clinical indexes were compared between the four groups. The correlation between IL-34, CTRP13 and WC, FPG, hs-CRP, Gensini score in the UA+T2DM group were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic values of IL-34 and CTRP13 for UA with T2DM. Results　The serum levels of IL-34 increased in the control group, T2DM group, UA group and UA+T2DM group in turn (all P＜0.05). The serum levels of CTRP13 decreased in the control group, UA group, T2DM group and UA+T2DM group in turn (all P＜0.05). The Gensini score was significantly higher in UA+T2DM group than that of UA group (P＜0.05). Correlation analysis showed that serum IL-34 level was positively correlated with WC, FPG, hs-CRP and Gensini score in UA+T2DM group, but negatively correlated with CTRP13 (all P＜0.05). The serum level of CTRP13 was negatively correlated with hs-CRP, FPG and Gensini score (all P＜0.05). The ROC curve showed that the areas under the curves of IL-34, CTRP13 and joint indicators were 0.784 (0.716-0.852), 0.820 (0.759-0.882) and 0.847 (0.787-0.906) in the diagnosis of UA with T2DM. Conclusion　The serum level of IL-34 is higher and the serum level of CTRP13 is lower in UA patients with T2DM. The serum levels of IL-34 and CTRP13 have predictive values for the diagnosis and the severity of coronary artery disease in UA with T2DM.

Key words: angina, unstable, diabetes mellitus, type 2, inflammation, interleukin 34, complement-C1q/TNF- related protein 13, glucose and lipid metabolism