自体富血小板血浆疗法在足底筋膜炎治疗中的临床应用进展

doi:10.11958/20252064

天津医药 ›› 2025, Vol. 53 ›› Issue (12): 1339-1344.doi: 10.11958/20252064

自体富血小板血浆疗法在足底筋膜炎治疗中的临床应用进展

柏天婷¹(), 王秀萍², 伏雅慧³, 刘璐¹, 刘国印¹^,^△()

¹ 南京大学医学院附属金陵医院（东部战区总医院）骨科（邮编210002）
² 南京大学医学院附属金陵医院（东部战区总医院）护理部
³ 南京大学医学院

收稿日期:2025-05-22 修回日期:2025-09-18 出版日期:2025-12-15 发布日期:2025-12-08
通讯作者: ^△E-mail：liuguoyin0425@163.com
作者简介:柏天婷（1987），女，硕士在读，主要从事肌腱病的基础和临床方面研究。E-mail：805807608@qq.com
基金资助:
国家自然科学基金青年科学基金(82102547);中国医药教育协会医药科技攻关重点课题(2024KTM021);东部战区总医院科技创新研究计划项目(2023YYHLZX187)

Clinical progress of autologous platelet-rich plasma therapy in the treatment of plantar fasciitis

BAI Tianting¹(), WANG Xiuping², FU Yahui³, LIU Lu¹, LIU Guoyin¹^,^△()

¹ Department of Orthopaedics, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
² Department of Nursing, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
³ Medical School of Nanjing University

Received:2025-05-22 Revised:2025-09-18 Published:2025-12-15 Online:2025-12-08
Contact: ^△E-mail：liuguoyin0425@163.com

柏天婷, 王秀萍, 伏雅慧, 刘璐, 刘国印. 自体富血小板血浆疗法在足底筋膜炎治疗中的临床应用进展[J]. 天津医药, 2025, 53(12): 1339-1344.

BAI Tianting, WANG Xiuping, FU Yahui, LIU Lu, LIU Guoyin. Clinical progress of autologous platelet-rich plasma therapy in the treatment of plantar fasciitis[J]. Tianjin Medical Journal, 2025, 53(12): 1339-1344.

摘要/Abstract

摘要：

足底筋膜炎（PF）是跟痛症（HP）的主要病因。富血小板血浆（PRP）作为一种新兴的生物治疗手段，具有独特的生物学特性，在抑制炎症反应和促进组织修复方面展现出显著的双重治疗优势。该文就PF的发病机制、PRP的生物学特性，以及PRP在PF的疼痛管理和功能预后评估中的应用，特别是PRP在改善足底筋膜厚度（PFT）中的应用予以综述。

关键词: 筋膜炎, 足底, 富血小板血浆, 疼痛管理, 自体, 足底筋膜厚度

Abstract:

Plantar fasciitis (PF) is a primary cause of heel pain (HP). Platelet-rich plasma (PRP), as an emerging biological treatment method, possesses unique biological characteristics, showing significant dual therapeutic advantages in suppressing inflammation and promoting tissue repair. This article reviews the pathogenesis of PF, the biological characteristics of PRP and its application in pain management and functional prognosis assessment of PF, particularly focusing on PRP in improving plantar fascia thickness (PFT).

Key words: fasciitis, plantar, platelet-rich plasma, pain management, autologous, plantar fascia thickness

中图分类号:

R493
R686.3

参考文献 47

[1]	RIEL H, GRIFFITHS I, HEIDE M, et al. Reinterpreting the clinical practice guidelines for plantar heel pain through an international lens[J]. J Orthop Sports Phys Ther, 2025, 55(1):72-73. doi:10.2519/jospt.2025.0202.
[2]	ROSA M V, PERSIANE A S, YI L C. Rethinking chronic plantar heel pain management:moving beyond mechanical models[J]. Br J Sports Med, 2025, 59(13):883-884. doi:10.1136/bjsports-2024-109348.
[3]	LANDORF K B, KAMINSKI M R, MUNTEANU S E, et al. Activity and footwear characteristics in people with and without plantar heel pain:A matched cross-sectional observational study[J]. Musculoskeletal Care, 2023, 21(1):35-44. doi:10.1002/msc.1663.
[4]	ALEID A M, ALYABIS N A, ALDANYOWI S N, et al. Efficacy of platelet-rich plasma versus corticosteroid injections in recovery from plantar fasciitis:A systematic review and meta-analysis[J]. J Taibah Univ Med Sci, 2025, 20(1):120-128. doi:10.1016/j.jtumed.2025.01.002.
[5]	HERBER A, COVARRUBIAS O, DAHER M, et al. Platelet rich plasma therapy versus other modalities for treatment of plantar fasciitis:A systematic review and meta-analysis[J]. Foot Ankle Surg, 2024, 30(4):285-293. doi:10.1016/j.fas.2024.02.004.
[6]	ZUO A, GAO C, JIA Q, et al. Platelet-rich plasma versus corticosteroids in the treatment of plantar fasciitis:a systematic review and Meta-analysis[J]. Am J Phys Med Rehabil, 2025, 104(7):613-621. doi:10.1097/PHM.0000000000002677.
[7]	DAHER M, COVARRUBIAS O, HERBER A, et al. Platelet-rich plasma vs extracorporeal shock wave therapy in the treatment of plantar fasciitis at 3-6 months:a systematic review and meta-analysis of randomized controlled trials[J]. Foot Ankle Int, 2024, 45(7):796-803. doi:10.1177/10711007241231959.
[8]	NAKAGAWA H F, KIM J, RINALDI J, et al. Systematic review of randomized controlled trials evaluating the use of platelet-rich plasma for knee osteoarthritis:adherence to minimum information for studies evaluating biologics in orthopaedics[J]. Am J Sports Med, 2025, 53(5):1241-1253. doi:10.1177/03635465241249996.
[9]	PLESEK J, HAMILL J, BURDA M, et al. Running distance and biomechanical risk factors for plantar fasciitis:a 1-yr prospective 4HAIE cohort study - corrigendum[J]. Med Sci Sports Exerc, 2025, 57(9):2100. doi:10.1249/MSS.0000000000003711.
[10]	LIEW S K, SAW A, CHUA Y P. Foot arch changes after endoscopic plantar fascia release for recalcitrant plantar fasciitis[J]. Malays Orthop J, 2022, 16(2):78-86. doi:10.5704/MOJ.2207.010.
[11]	TAKAHASHI N, OHTORI S, SAISU T, et al. Second application of low-energy shock waves has a cumulative effect on free nerve endings[J]. Clin Orthop Relat Res, 2006, 443:315-319. doi:10.1097/01.blo.0000188064.56091.a7.
[12]	SHEHU S U, YILMAZ A E, ÖRSÇELI K A, et al. Comparison of balance performance,gait,foot function,lower extremity biomechanical alignment and muscle strength in individuals with unilateral and bilateral plantar fasciitis[J]. Gait Posture, 2025, 119:143-149. doi:10.1016/j.gaitpost.2025.03.003.
[13]	LATT L D, JAFFE D E, TANG Y, et al. Evaluation and treatment of chronic plantar fasciitis[J]. Foot Ankle Orthop, 2020, 5(1):2473011419896763. doi:10.1177/2473011419896763.
[14]	KOC T A Jr, BISE C G, NEVILLE C, et al. Heel pain - plantar fasciitis:revision 2023[J]. J Orthop Sports Phys Ther, 2023, 53(12):CPG1-CPG39. doi:10.2519/jospt.2023.0303.
[15]	ÇIFTCI İNCEOĞLU S, AYYILDIZ A, KURAN B. Effects of kinesio taping versus extracorporeal shock wave therapy on pain in the treatment of plantar heel pain secondary to plantar fasciitis and a calcaneal spur:A retrospective clinical trial[J]. J Foot Ankle Surg, 2025, 64(5):541-545. doi:10.1053/j.jfas.2025.03.011.
[16]	KUMAR S, CHANNAVEERA C, SETHI S, et al. To evaluate efficacy of intralesional platelet rich plasma in patients with plantar fasciitis[J]. J Am Podiatr Med Assoc, 2025:1-24. doi:10.7547/24-161.[Online ahead of print].
[17]	KUMARI N, MISHRA S R, GUPTA A K, et al. Ultrasonography-guided dextrose prolotherapy versus platelet-rich plasma injections for the treatment of plantar fasciitis:a randomized controlled trial[J]. Cureus, 2025, 17(1):e77566. doi:10.7759/cureus.77566.
[18]	SATHYENDRA K G, DNYANDEO SOLANKEY R, SINGH M, et al. Comparative study of local injections of autologous platelet rich plasma versus corticosteroid in management of chronic plantar fasciitis[J]. J Clin Orthop Trauma, 2023,43:102225. doi:10.1016/j.jcot.2023.102225.
[19]	KHURANA A, DHANKHAR V, GOEL N, et al. Comparison of midterm results of platelet rich plasma (PRP) versus Steroid for plantar fasciitis:A randomized control trial of 118 patients[J]. J Clin Orthop Trauma, 2021, 13:9-14. doi:10.1016/j.jcot.2020.09.002.
[20]	KUMAR K, RAO V, PANDA A, et al. Comparison of platelet-rich plasma and corticosteroid injections for chronic plantar fasciitis:a randomized controlled trial[J]. Cureus, 2024, 16(5):e59656. doi:10.7759/cureus.59656.
[21]	SHARMA R, CHAUDHARY N K, KARKI M, et al. Effect of platelet-rich plasma versus steroid injection in plantar fasciitis:a randomized clinical trial[J]. BMC Musculoskelet Disord, 2023, 24(1):172. doi:10.1186/s12891-023-06277-1.
[22]	GURUN E, OZTURK M, CAKIR I M, et al. Evaluation of the effectiveness of ultrasound-guided corticosteroid injection treatment in plantar fasciitis using shear wave elastography[J]. Eur J Radiol, 2025,187:112092. doi:10.1016/j.ejrad.2025.112092.
[23]	GÖKALP O, İLYAS G. Short-term load restriction after autologous whole-blood injection enhances early recovery in Plantar Fasciitis:A prospective randomized single-blinded trial[J]. J Foot Ankle Surg, 2025, 64(4):488-493. doi:10.1053/j.jfas.2025.03.005.
[24]	JO C H, LEE S Y, YOON K S, et al. Allogeneic platelet-rich plasma versus corticosteroid injection for the treatment of rotator cuff disease:a randomized controlled trial[J]. J Bone Joint Surg Am, 2020, 102(24):2129-2137. doi:10.2106/JBJS.19.01411.
[25]	AKTAN Ç, AKTAN C. Comparative effectiveness of ultrasound-guided corticosteroid injection,radiofrequency ablation,and their combination for recalcitrant plantar fasciitis:a retrospective cohort study[J]. J Foot Ankle Res, 2025, 18(3):e70080. doi:10.1002/jfa2.70080.
[26]	KARAKıLıÇ G D, ARAS M, BÜYÜK F, et al. Prolotherapy versus phonophoresis and corticosteroid injections for the treatment of plantar fasciitis:a randomized,double-blind clinical trial[J]. J Foot Ankle Surg, 2023, 62(6):922-927. doi:10.1053/j.jfas.2023.04.010.
[27]	TAN V, TAN C C, YEO N, et al. Consensus statements and guideline for the diagnosis and management of plantar fasciitis in Singapore[J]. Ann Acad Med Singap, 2024, 53(2):101-112. doi:10.47102/annals-acadmedsg.2023211.
[28]	邢更彦, 张浩冲, 刘水涛, 等. 中国骨肌疾病体外冲击波疗法指南(2019年版)[J]. 中国医学前沿杂志(电子版), 2019,11(4):1-10.
	XING G Y, ZHANG H C, LIU S T, et al. Guidelines for Extracorporeal Shock Wave Therapy for Bone and Muscle Disorders in China (2019 Edition)[J]. Chinese Journal of the Frontiers of Medical Science(Electronic Version), 2019, 11(4):1-10. doi:10.12037/YXQY.2019.04-01.
[29]	中国研究型医院学会冲击波医学专业委员会, 邢更彦, 张志杰, 等. 中国骨肌疾病体外冲击波疗法指南(2023年版)[J]. 中国医学前沿杂志(电子版), 2023,15(9):1-20.
	Shock Wave Medicine Professional Committee, Chinese Society of Research Hospital, XING G Y, ZHANG Z J, et al. Chinese guidelines for extracorporeal shock wave therapy for bone and muscle diseases(2023 edition)[J]. Chinese Journal of the Frontiers of Medical Science(Electronic Version), 2023, 15(9):1-20. doi:10.12037/YXQY.2023.09-01.
[30]	HSIAO M Y, HUNG C Y, CHANG K V, et al. Comparative effectiveness of autologous blood-derived products,shock-wave therapy and corticosteroids for treatment of plantar fasciitis:a network meta-analysis[J]. Rheumatology(Oxford), 2015, 54(9):1735-1743. doi:10.1093/rheumatology/kev010.
[31]	JOSHI A, COLLAZO C, LAIDLEY Z, et al. Validation of the foot and ankle outcome score for use in infracalcaneal heel pain[J]. J Foot Ankle Surg, 2023, 62(3):501-504. doi:10.1053/j.jfas.2022.12.003.
[32]	KIM N, JACOBSON M. Outcomes by race and ethnicity following a medicare bundled payment program for joint replacement[J]. JAMA Netw Open, 2024, 7(9):e2433962. doi:10.1001/jamanetworkopen.2024.33962.
[33]	SINGH H, TYAGI S, QAMAR R, et al. Functional outcomes after injections of platelet-rich plasma for plantar fasciitis[J]. Cureus, 2025, 17(4):e83276. doi:10.7759/cureus.83276.
[34]	SHAH H, PRABHAKARAN A, PRAVEEN I, et al. A Comparative study of platelet-rich plasma v/s corticosteroid injection for plantar fasciitis[J]. J Pharm Bioallied Sci, 2025, 17(Suppl 2):S1689-S1691. doi:10.4103/jpbs.jpbs_263_25.
[35]	GOH G S, TAY A, RIKHRAJ I S, et al. Defining the patient acceptable symptom state for the American Orthopaedic Foot & Ankle Society score following hallux valgus surgery[J]. Foot Ankle Surg, 2021, 27(5):528-534. doi:10.1016/j.fas.2020.06.013.
[36]	FRANK V J, LICHTE P, GUTTECK N, et al. Comparison of the European Foot and Ankle Score (EFAS) and the American Orthopedic Foot and Ankle Society Score (AOFAS) in patients with foot and ankle surgery[J]. Foot Ankle Surg,2025 doi:10.1016/j.fas.2025.04.008.
[37]	HIJJI F Y, SCHNEIDER A D, PYPER M, et al. The Popularity of outcome measures used in the foot and ankle literature[J]. Foot Ankle Spec, 2020, 13(1):58-68. doi:10.1177/1938640019826680.
[38]	MAHOWALD S, LEGGE B S, GRADY J F. The correlation between plantar fascia thickness and symptoms of plantar fasciitis[J]. J Am Podiatr Med Assoc, 2011, 101(5):385-389. doi:10.7547/1010385.
[39]	BM S A, TIWARI V, BAKDE A M, et al. Ultrasonographic assessment of indian patients with plantar fasciitis and its clinical correlation:a prospective observational study[J]. Cureus, 2023, 15(3):e35764. doi:10.7759/cureus.35764.
[40]	GATZ M, BEJDER L, QUACK V, et al. Shear wave elastography (SWE) for the evaluation of patients with plantar fasciitis[J]. Acad Radiol, 2020, 27(3):363-370. doi:10.1016/j.acra.2019.04.009.
[41]	SLAYTON M H, AMODEI R C, COMPTON K B, et al. Retrospective analysis of plantar fascia by ultrasound imaging in patients with plantar fasciitis[J]. J Am Podiatr Med Assoc, 2018, 108(5):349-354. doi:10.7547/16-083.
[42]	BAUR D, SCHWABL C, KREMSER C, et al. Shear wave elastography of the plantar fascia:comparison between patients with plantar fasciitis and healthy control subjects[J]. J Clin Med, 2021, 10(11):2351. doi:10.3390/jcm10112351.
[43]	VELLINGIRI K, S N J, P V M, et al. A prospective study comparing the efficacy of local injection of platelet-rich plasma (PRP) vs methylprednisolone in plantar fasciitis[J]. Cureus, 2022, 14(5):e25523. doi:10.7759/cureus.25523.
[44]	THANWISATE T, SIRIWANARANGSUN P, PIYASELAKUL S, et al. Plantar fascia thickness and stiffness in healthy individuals vs patients with plantar fasciitis[J]. Foot Ankle Int, 2024, 45(11):1270-1278. doi:10.1177/10711007241274765.
[45]	HIRAKAWA K, TSUTSUMI M, KUDO S. Investigation of the relationship between the thickness of the plantar calcaneonavicular ligament and plantar fascia in patients with plantar fasciitis[J]. Foot (Edinb), 2022,50:101890. doi:10.1016/j.foot.2021.101890.
[46]	ERMUTLU C, AKSAKAL M, GÜMÜŞTAŞ A, et al. Thickness of plantar fascia is not predictive of functional outcome in plantar fasciitis treatment[J]. Acta Orthop Traumatol Turc, 2018, 52(6):442-446. doi:10.1016/j.aott.2018.01.002.
[47]	LIANG J, YANG Y, YU G, et al. Deformation and stress distribution of the human foot after plantar ligaments release:a cadaveric study and finite element analysis[J]. Sci China Life Sci, 2011, 54(3):267-271. doi:10.1007/s11427-011-4139-0.

自体富血小板血浆疗法在足底筋膜炎治疗中的临床应用进展

Clinical progress of autologous platelet-rich plasma therapy in the treatment of plantar fasciitis

引用本文

RichHTML

PDF (PC)

可视化

摘要/Abstract

使用本文

参考文献 47

相关文章 15

编辑推荐

Metrics

本文评价

[1]	陈丹丹, 万业达, 何辉, 刘妍. 超声造影评价甲状旁腺自体异位移植成活价值的初步研究[J]. 天津医药, 2022, 50(9): 980-983.
[2]	刘思婧, 张潇, 李益, 罗茂, 吴剑波, 李蓉 △. 富含血小板血浆修复小鼠皮肤组织缺损创面的实验研究[J]. 天津医药, 2020, 48(6): 522-526.
[3]	张庆芬, 吴雅青, 冯艺. 骶骨肿瘤切除术围术期疼痛及管理现状分析[J]. 天津医药, 2020, 48(12): 1205-1210.
[4]	张辉 1，林松 2，熊希倩 3，闫学强 3，余晨 3，高伟 4，胡晓丽 5，赵丽 5，詹江华 1△. 胆管板畸形对胆道闭锁患儿自体肝生存的影响[J]. 天津医药, 2019, 47(4): 346-350.
[5]	郝胜利, 刘琳. 眼睑修复重建手术中睑板替代物的研究进展[J]. 天津医药, 2019, 47(12): 1277-1280.
[6]	谭学惠, 卢晶晶, 杨一楠, 韦芳宁, 谢娟, 熊成艳, 韦娟, 古小洪. 局部外用桂龙护瘘涂膜剂对血液透析患者炎症因子及自体动静脉内瘘成熟状态的影响[J]. 天津医药, 2019, 47(12): 1244-1247.
[7]	余晨 , 熊希倩 , 詹江华 , 胡晓丽 , 高伟 . MMP-7在胆道闭锁肝纤维化患者中的表达及临床意义[J]. 天津医药, 2019, 47(1): 38-42.
[8]	陈扬詹江华. 胆道闭锁kasai术后自体肝生存情况研究进展[J]. 天津医药, 2016, 44(7): 829-833.
[9]	赵晓涛，高翔△，张殿英，郁凯，董胜利，李建鹏. 关节融合术治疗重度僵硬 30 例疗效分析[J]. 天津医药, 2015, 43(3): 308-310.
[10]	王磊. 氨甲环酸关节腔内注射和自体血回吸收器对TKA术后失血的影响[J]. , 2013, 41(8): 0-746 .
[11]	高翔,赵晓涛,陈玉宏,张殿英. 改良第一跖骨远端V形截骨术治疗轻中度拇外翻[J]. , 2013, (10): 0-0 .
[12]	唐纯海1 ,吴全理2 . 术前急性等容血液稀释联合术中自体血回收在神经外科手术中的应用[J]. , 2012, 40(2): 178-179 .
[13]	吴建华1 ,施辉2 ,3 ,王锋2 ,3 ,张义德2 ,4 . 自体动静脉内瘘反复功能丧失患者血小板功能分析[J]. , 2011, 39(9): 794-796 .
[14]	骆巍. 环锯减压原位植骨钢板内固定治疗颈椎病疗效分析[J]. , 2011, 39(11): 1078-1079 .
[15]	曹晓娜1 ,熊蔚莉2 ,李敬华2 ,胡丽玲3 ,梁东春4 ,孙蓓5 ,左爱军2 . 组织工程自体骨修复兔大块骨缺损[J]. , 2010, 38(4): 0-0 .