天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (7): 829-833.doi: 10.11958/20160237

• 专题研究·胆道闭锁与肝移植 • 上一篇    下一篇

胆道闭锁kasai术后自体肝生存情况研究进展

陈扬1,詹江华2   

  1. 1 天津医科大学研究生院（邮编 300070）；2天津市儿童医院外科， 天津市儿科研究所
  • 收稿日期:2016-04-05 修回日期:2016-04-17 出版日期:2016-07-15 发布日期:2016-07-15
  • 通讯作者: 詹江华 E-mail:18203410933@163.com
  • 作者简介:陈扬（1991）， 女， 硕士在读， 主要从事胆道闭锁方面研究
  • 基金资助:
    国家自然科学基金资助项目（81570471）；天津市卫计委重大攻关项目（14KG129）

Study of the native liver survival of children with biliary atresia after kasai operation

CHEN Yang ,ZHAN Jianghua   

  1. 1 The Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Tianjin Children’ s Hospital, Tianjin Pediatric Institution
  • Received:2016-04-05 Revised:2016-04-17 Published:2016-07-15 Online:2016-07-15
  • Contact: ZHAN Jianghua E-mail:18203410933@163.com

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摘要： 胆道闭锁（biliary atresia,BA）是一种病因未明、以进行性炎症和纤维化为特征的阻塞性胆管病变。肝门空肠吻合术（kasai portoenterostomy）是目前治疗胆道闭锁的主要手术方式，但约80％的患儿kasai术后效果不佳需要肝移植。影响BA 患儿kasai术后自体肝生存的因素有很多，包括胆道闭锁分型、腹腔镜下kasai手术还是传统的开腹kasai手术、患儿kasai术时年龄、术时肝脏病变情况、术后黄疸清除情况、胆管炎发生情况、术后是否使用激素以及是否中心式集中管理等，本文就影响BA患儿kasai术后自体肝生存的相关因素作一综述。

关键词: 胆道闭锁, 肝移植, 预后, 综述, kasai手术, 自体肝生存

Abstract: Biliary atresia (BA) is a kind of obstructive biliary disease, with progressive inflammation and fibrosis characteristics . Kasai portoenterostomy is the only method of treatment of biliary atresia, but 80% of the patients treated by kasai operation still need liver transplantation in the future. There are many factors, such as the types of BA，laparoscopic kasai surgery or traditional open surgery， patient’s age at surgery, condition of liver function, occurrence of cholangitis, jaundice clearance, using of steroids and central hospitalization to influent the native liver survival and to be reviewed as following below.

Key words: Biliary atresia (BA), liver transplantation, prognosis, review, kasai operation, native liver survival