天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 879-882.doi: 10.11958/j.issn.0253-9896.2015.08.013

• 临床研究 • 上一篇    下一篇

新疆锡伯族、蒙古族高血压患者血清CyPA 水平变化及其临床意义

王忠，郑丽华，巴音巴特，徐晓红，王春勇，任宏强，赵若飞   

  1. 1新疆石河子大学医学院第一附属医院心内二科（邮编832000）；2新疆石河子大学医学院；3新疆博尔塔拉蒙古自治州人民医院心内科；4新疆察布查尔锡伯自治县人民医院
  • 收稿日期:2015-01-06 修回日期:2015-03-20 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 巴音巴特 E-mail:709723926@qq.com
  • 作者简介:王忠（1964），男，教授，博士，主任医师，主要从事高血压及其发病机制研究
  • 基金资助:
    新疆兵团医药卫生专项基金资助项目（2012AB014）

Correlation of serum cyclophilin A level with occurance of essential hypertension in Xinjiang Xibo and Mongolia populations and its clinical significance

WANG Zhong, ZHENG Lihua, BAYINBATE, XU Xiaohong, WANG Chunyong, REN Hongqiang, ZHAO Ruofei   

  1. 1 Department of Cardiology, the First Affiliated Hospital of Medical College of Shihezi University, Xinjiang 832000, China; 2 Medical College of Shihezi University;3 Department of Cardiology, the People′s Hospital of Xinjiang Bortala Mongol Autonomous Prefecture；4 People′s Hospital of Xinjiang Qapqal Xibo Autonomous Prefecture
  • Received:2015-01-06 Revised:2015-03-20 Published:2015-08-15 Online:2015-08-15

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摘要： 目的观察新疆锡伯族、蒙古族原发性高血压（EH）患者血清亲环素A（CyPA）水平并探讨其临床意义。方法选取锡伯族EH 患者76 例和健康对照者62 例，蒙古族EH 患者66 例和健康对照者57 例。采用酶联免疫吸附法（ELISA）测定血清CyPA，检测各组的年龄、体质量指数（BMI）、腰围、腰臀比、血压等各项指标，并分析血清CyPA 与各指标的相关性。结果新疆锡伯族、蒙古族EH 组血清CyPA 水平均显著高于健康对照组（P＜0.05）；蒙古族 EH 组血清CyPA 水平显著高于锡伯族EH 组（P＜0.05）；高血压患者血清CyPA 水平与血压呈正相关（P＜0.05）。结论新疆锡伯族、蒙古族EH 患者血清CyPA 明显升高，并与血压存在一定的相关性。血清CyPA 升高是新疆锡伯族、蒙古族EH 的危险因素。

关键词: 高血压, 亲环素A, 血压, 锡伯族, 蒙古族

Abstract: Objective To investigate the correlation of cyclophilin A (CyPA) level in patients with essential hyperten⁃ sion（EH）in Xinjiang Xibo and Mongolia populations and to investigate its clinical significance. Methods EH patients (n= 76) and healthy control subjects (n=62) were selected from Xinjiang Xibo populations. On the other hand, EH patients (n=66) and healthy control subjects (n=57) were selected from Xinjiang Mongolia populations. Serum cyclophilin A was measured using enzyme-linked immunosorbent assay（ELISA）. Parameters such as age, body mass index（BMI）, waist, waist hip ratio, blood pressure were measured in each group. The correlation of cyclophilin A with each parameter was analyzed. Results The levels of serum cyclophilin A in EH patients in Xinjiang Xibo and Xinjiang Mongolia populations were significantly high⁃ er than those in their corresponding healthy control groups(P＜0.05). Serum cyclophilin A in patients with essential hyperten⁃ sion（EH）in Xinjiang Mongolia population was signifantly higher than that in EH patients from Xinjiang Xibo population (P＜0.05). There was a positive correlation between serum cyclophilin A level and occurance of EH in both Xinjiang Xibo and Xinjiang Mongolia populations. Conclusion The serum cyclophilin A is significant higher in EH patients in both Xinji⁃ ang Xibo and Xinjiang Mongolia populations so it is positively correlated with occurance of EH (P＜0.05). Cyclophilin A lev⁃ el is a risk factor of essential hypertension in both Xinjiang Xibo and Xinjiang Mongolia populations.

Key words: hypertension, cyclophilin A, blood pressure, Xibo populations, Mongolia populations