天津医药

天津医药 ›› 2014, Vol. 42 ›› Issue (12): 1243-1245.doi: 10.3969/j.issn.0253-9896.2014.12.026

• 综述 • 上一篇    下一篇

IL-35及其免疫抑制功能的研究进展

闫永嘉,何向辉   

  1. 天津医科大学总医院
  • 收稿日期:2014-02-21 修回日期:2014-07-11 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 何向辉 E-mail:humphreyhe@163.com

Review the Function and Structure of Interleukin-35 and Its Function in Mediating Treg Cell Immuno-Suppression

YAN Yongjia ,HE Xianghui   

  1. Department of General Surgery, the General Hospital of Tianjin Medical University, Tianjin 300052, China
  • Received:2014-02-21 Revised:2014-07-11 Published:2014-12-15 Online:2014-12-15
  • Contact: HE Xianghui E-mail:humphreyhe@163.com

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摘要：

【摘要】 白细胞介素（IL）-35 是新发现的 IL-12 家族新成员， 由调节性 T 细胞分泌， 可以直接或间接地发挥强大的免疫抑制作用。 目前针对 IL-35 免疫抑制作用与自身免疫病、炎症性疾病和肿瘤关系的研究逐渐成为热点。 本文综述了 IL-35 的特征和其发挥免疫抑制作用的机制。

关键词: T 淋巴细胞, 调节性, 自身免疫疾病, 免疫耐受, IL-35, iTR35 细胞

Abstract:

[Abstract] Interleukin (IL)-35 is a new member of IL-12 family who is secreted by T regulatory cells to strongly sup? press immuno reaction directly or indirectly. There is a growing interest in the using IL-35 as a potential therapy for chronic in? flammatory , cancer and autoimmune diseases. Here we reviewed IL-35 and its function as a mediator of suppression.

Key words: T-lymphocytes, regulatory, autoimmune diseases, immune tolerance, IL-35, iTR35 cells