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cyclinD1在卵巢子宫内膜异位症中的表达及临床意义

张爱群   

  1. 白求恩军医学院附属第260医院
  • 收稿日期:2010-01-13 修回日期:2010-05-13 出版日期:2010-11-15 发布日期:2010-11-15
  • 通讯作者: 张爱群

Expression and Clinical Significance of CyclinD1 in Endometriosis of Ovary

  • Received:2010-01-13 Revised:2010-05-13 Published:2010-11-15 Online:2010-11-15

摘要: 【摘要】 目的:探讨cyclinD1在卵巢子宫内膜异位症中的表达及临床意义。方法:采用免疫组织化学的方法(S-P)检测cyclinD1 在卵巢子宫内膜异位症(43例)及正常子宫内膜组织(27)中的表达。结果:cyclinD1在卵巢子宫内膜异位症中的表达明显高于正常子宫内膜组织,统计学处理差异有显著性(p<0.05)。cyclinD1 与痛经、月经异常、不孕无明显关系,而与囊肿大小、异位内膜浸润深度及盆腔浸润情况关系密切,统计学处理差异有显著性(p<0.05)。结论:cyclinD1与卵巢子宫内膜异位症的发生、发展关系密切。 【关键词】卵巢子宫内膜异位症; cyclinD1;细胞周期;免疫组织化学

关键词: 卵巢子宫内膜异位症, cyclinD1, 细胞周期, 免疫组织化学

Abstract: Abstract:【objective】Investigate the Presentation and Clinical Significance of CyclinD1 in Endometriosis of Ovary. 【Methods】 Apply immunohistochemistry (s-p) method to detect the presentation of CyclinD1 in 43 tissues of endometriosis of ovary and 27 tissues of normal endometrium. 【Results】CyclinD1 in endometriosis of ovary is clearly higher than that in normal endimetrium with statistical significance (P<0.05). The high expression of CyclineD1 in endometriosis of ovary is not clearly related to dysmenorrheal, abnormal menstruation and barren, but is clearly related to the sizes of cysts,the depths of ectopia intima imbibition and the imbibition condition of pelvic cavity. Their relation has statistical significance.(P<0.05). 【Conclusion】 CyclinD1 is closely related to the development of endometriosis of ovary.

Key words: Endometriosis of ovary, cyclinD1, Cell cycle, Immumohistochemistry