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甲型H1N1流感病例血清酶学改变初探

史丽霞1,吴琦2,武俊平3,华静娜4,谢祎5,杜钟珍5   

  1. 1. 天津市海河医院天津市呼吸疾病研究所
    2. 海河医院
    3. 天津市海河医院呼吸科
    4. 天津市海河医院
    5.
  • 收稿日期:2009-12-24 修回日期:2010-05-01 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 华静娜

An initial observation on the variation of the enzyme in serum of patients with type A(H1N1) influenza

  • Received:2009-12-24 Revised:2010-05-01 Published:2010-10-15 Online:2010-10-15

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摘要： [摘要] 目的：探讨甲型H1N1流感重症患者与轻症患者之间,各组不同时间点之间血清酶学（转氨酶和心肌酶）的异同，了解其临床意义，并推论可能的原因。 方法：选取甲型H1N1流感重症和轻症患者各10例，将入院当天、第3天和第7天丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、乳酸脱氢酶（LDH）、血清肌酸激酶(CK)和肌酸激酶同工酶(CK -MB)各值进行组间比较，并将重症组和轻症组不同时间点之间进行比较。 结果：重症组与轻症组之间各个时间ALT、AST、LDH、CK-MB均存在统计学差异（p<0.05），入院当天组间CK比较存在统计学差异，但第3天和第7天两组之间比较无统计学差异。重症组不同时间点之间比较，除CK入院当天分别与第3天，第7天之间比较有统计学差异(P<0.05)，其余均无统计学差异；轻症组不同时间点之间比较均无统计学差异。 结论：甲型H1N1流感重症患者血清酶学均较轻症患者明显升高，提示重症患者存在肝脏和心肌的损害。重症患者肝脏和心肌损害机制需进一步研究。至入院一周，重症组、轻症组不同时间点之间酶学变化不大。 关键词：甲型H1N1流感；转氨酶；心肌酶

关键词: 甲型H1N1流感, 转氨酶, 心肌酶

Abstract: [ Abstract ] Objective : To find out the difference of the enzyme in serum between the severe case and mild case with H1N1 influenza and between the groups at different time points, to understand its clinical significance, and infer possible reasons. Methods :We selected H1N1 influenza in patients with severe and mild respectively 10 cases who admitted to hospital the first day, the third day and the seventh day of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), serum creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) of all values between the two groups, and severe group and mild group comparisons between different time points. Results : There were significant difference (p <0.05) between severe group and mild group in ALT, AST, LDH, CK-MB at all time points. There was significant difference between severe group and mild group in CK at the admission day ,but no significant difference between the two groups in CK at the the third day and the seventh day. There was significant difference between the admission day and the third, the seventh day respectively in CK in severe group. There was no statistical difference among different time points in severe group in ALT, AST, LDH, CK-MB. There was no statistical difference among different time points in mild group. Conclusion : The enzyme in severe group patients with H1N1 influenza was significantly higher than those in mild patients, suggesting the liver and myocardial damaged in severe patients . The mechanism of liver and myocardial damage in severe patients would need further study .The enzyme between two groups at different time points changed little in one week after hospitalization. [ Key words] type A(H1N1) influenza; aminotransferase; myocardial enzyme

Key words: type A(H1N1) influenza, aminotransferase, myocardial enzyme